A novel IgG Fc by computer-aided design enhances heavy-chain heterodimerization in bi- or trispecific antibodies

The classical `knob-into-holes' (KIH) strategy (knob(T366Y)/hole (Y407T)) has successfully enhanced the heterodimerization of a bispecific antibody (BsAb) resulting in heterodimer formation up to 92% of protein A (ProA)-purified protein pool. However, it does not show high efficiency for every...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Lin, Jun, Hoag, Matthew R, Wright, Meredith, Ma, Mingjun, Cai, Wenyan, Gallolu Kankanamalage, Sachith, Liu, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413979/
https://www.ncbi.nlm.nih.gov/pubmed/36042698
http://dx.doi.org/10.1093/abt/tbac019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413979/
https://www.ncbi.nlm.nih.gov/pubmed/36042698
http://dx.doi.org/10.1093/abt/tbac019

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