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Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development

Advancement in novel target detection using improved molecular cancer biology has opened up new avenues for promising anti-cancer drug development. In the past two decades, the mechanism of tumor hypoxia has become more understandable with the discovery of hypoxia-inducible factor-1α (HIF-1α). It is...

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Autores principales: Ghosh, Rituparna, Samanta, Priya, Sarkar, Rupali, Biswas, Souradeep, Saha, Prosenjit, Hajra, Subhadip, Bhowmik, Arijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413992/
https://www.ncbi.nlm.nih.gov/pubmed/36014432
http://dx.doi.org/10.3390/molecules27165192
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author Ghosh, Rituparna
Samanta, Priya
Sarkar, Rupali
Biswas, Souradeep
Saha, Prosenjit
Hajra, Subhadip
Bhowmik, Arijit
author_facet Ghosh, Rituparna
Samanta, Priya
Sarkar, Rupali
Biswas, Souradeep
Saha, Prosenjit
Hajra, Subhadip
Bhowmik, Arijit
author_sort Ghosh, Rituparna
collection PubMed
description Advancement in novel target detection using improved molecular cancer biology has opened up new avenues for promising anti-cancer drug development. In the past two decades, the mechanism of tumor hypoxia has become more understandable with the discovery of hypoxia-inducible factor-1α (HIF-1α). It is a major transcriptional regulator that coordinates the activity of various transcription factors and their downstream molecules involved in tumorigenesis. HIF-1α not only plays a crucial role in the adaptation of tumor cells to hypoxia but also regulates different biological processes, including cell proliferation, survival, cellular metabolism, angiogenesis, metastasis, cancer stem cell maintenance, and propagation. Therefore, HIF-1α overexpression is strongly associated with poor prognosis in patients with different solid cancers. Hence, pharmacological targeting of HIF-1α has been considered to be a novel cancer therapeutic strategy in recent years. In this review, we provide brief descriptions of natural and synthetic compounds as HIF-1α inhibitors that have the potential to accelerate anticancer drug discovery. This review also introduces the mode of action of these compounds for a better understanding of the chemical leads, which could be useful as cancer therapeutics in the future.
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spelling pubmed-94139922022-08-27 Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development Ghosh, Rituparna Samanta, Priya Sarkar, Rupali Biswas, Souradeep Saha, Prosenjit Hajra, Subhadip Bhowmik, Arijit Molecules Review Advancement in novel target detection using improved molecular cancer biology has opened up new avenues for promising anti-cancer drug development. In the past two decades, the mechanism of tumor hypoxia has become more understandable with the discovery of hypoxia-inducible factor-1α (HIF-1α). It is a major transcriptional regulator that coordinates the activity of various transcription factors and their downstream molecules involved in tumorigenesis. HIF-1α not only plays a crucial role in the adaptation of tumor cells to hypoxia but also regulates different biological processes, including cell proliferation, survival, cellular metabolism, angiogenesis, metastasis, cancer stem cell maintenance, and propagation. Therefore, HIF-1α overexpression is strongly associated with poor prognosis in patients with different solid cancers. Hence, pharmacological targeting of HIF-1α has been considered to be a novel cancer therapeutic strategy in recent years. In this review, we provide brief descriptions of natural and synthetic compounds as HIF-1α inhibitors that have the potential to accelerate anticancer drug discovery. This review also introduces the mode of action of these compounds for a better understanding of the chemical leads, which could be useful as cancer therapeutics in the future. MDPI 2022-08-15 /pmc/articles/PMC9413992/ /pubmed/36014432 http://dx.doi.org/10.3390/molecules27165192 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghosh, Rituparna
Samanta, Priya
Sarkar, Rupali
Biswas, Souradeep
Saha, Prosenjit
Hajra, Subhadip
Bhowmik, Arijit
Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development
title Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development
title_full Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development
title_fullStr Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development
title_full_unstemmed Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development
title_short Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development
title_sort targeting hif-1α by natural and synthetic compounds: a promising approach for anti-cancer therapeutics development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413992/
https://www.ncbi.nlm.nih.gov/pubmed/36014432
http://dx.doi.org/10.3390/molecules27165192
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