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Pregnancy and COVID-19: The Possible Contribution of Vitamin D

Background: Vitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SA...

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Autores principales: Manca, Alessandra, Cosma, Stefano, Palermiti, Alice, Costanzo, Martina, Antonucci, Miriam, De Vivo, Elisa Delia, Ianniello, Alice, Borella, Fulvio, Carosso, Andrea Roberto, Corcione, Silvia, De Rosa, Francesco Giuseppe, Benedetto, Chiara, D’Avolio, Antonio, Cusato, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414046/
https://www.ncbi.nlm.nih.gov/pubmed/36014781
http://dx.doi.org/10.3390/nu14163275
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author Manca, Alessandra
Cosma, Stefano
Palermiti, Alice
Costanzo, Martina
Antonucci, Miriam
De Vivo, Elisa Delia
Ianniello, Alice
Borella, Fulvio
Carosso, Andrea Roberto
Corcione, Silvia
De Rosa, Francesco Giuseppe
Benedetto, Chiara
D’Avolio, Antonio
Cusato, Jessica
author_facet Manca, Alessandra
Cosma, Stefano
Palermiti, Alice
Costanzo, Martina
Antonucci, Miriam
De Vivo, Elisa Delia
Ianniello, Alice
Borella, Fulvio
Carosso, Andrea Roberto
Corcione, Silvia
De Rosa, Francesco Giuseppe
Benedetto, Chiara
D’Avolio, Antonio
Cusato, Jessica
author_sort Manca, Alessandra
collection PubMed
description Background: Vitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SARS-CoV-2 positive and negative patients. Methods: Vitamin D pathway related polymorphisms and 25-hydroxyvitamin D levels were quantified in pregnant women followed from the first to the third trimester of pregnancy. Vitamin D deficiency was considered with values ≤ 30 ng/mL. Results: In total, 160 women were enrolled: 23 resulted positive for at least one SARS-CoV-2 related test (molecular swab or antibody tests). Vitamin D-associated polymorphisms were able to affect vitamin D levels in SARS-CoV-2 negative and positive subjects: remarkably, all the VDR TaqICC genotype patients were negative for SARS-CoV-2. In a sub-population (118 patients), vitamin D levels correlated with pregnancy-related factors, such as alpha-fetoprotein levels. Third-trimester vitamin D levels were lower in preterm births compared to full-term pregnancy: this trend was highlighted for SARS-CoV-2 positive patients. Conclusions: This is the first study demonstrating a role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Further studies in larger and different cohorts of patients are required to confirm these findings.
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spelling pubmed-94140462022-08-27 Pregnancy and COVID-19: The Possible Contribution of Vitamin D Manca, Alessandra Cosma, Stefano Palermiti, Alice Costanzo, Martina Antonucci, Miriam De Vivo, Elisa Delia Ianniello, Alice Borella, Fulvio Carosso, Andrea Roberto Corcione, Silvia De Rosa, Francesco Giuseppe Benedetto, Chiara D’Avolio, Antonio Cusato, Jessica Nutrients Article Background: Vitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SARS-CoV-2 positive and negative patients. Methods: Vitamin D pathway related polymorphisms and 25-hydroxyvitamin D levels were quantified in pregnant women followed from the first to the third trimester of pregnancy. Vitamin D deficiency was considered with values ≤ 30 ng/mL. Results: In total, 160 women were enrolled: 23 resulted positive for at least one SARS-CoV-2 related test (molecular swab or antibody tests). Vitamin D-associated polymorphisms were able to affect vitamin D levels in SARS-CoV-2 negative and positive subjects: remarkably, all the VDR TaqICC genotype patients were negative for SARS-CoV-2. In a sub-population (118 patients), vitamin D levels correlated with pregnancy-related factors, such as alpha-fetoprotein levels. Third-trimester vitamin D levels were lower in preterm births compared to full-term pregnancy: this trend was highlighted for SARS-CoV-2 positive patients. Conclusions: This is the first study demonstrating a role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Further studies in larger and different cohorts of patients are required to confirm these findings. MDPI 2022-08-10 /pmc/articles/PMC9414046/ /pubmed/36014781 http://dx.doi.org/10.3390/nu14163275 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manca, Alessandra
Cosma, Stefano
Palermiti, Alice
Costanzo, Martina
Antonucci, Miriam
De Vivo, Elisa Delia
Ianniello, Alice
Borella, Fulvio
Carosso, Andrea Roberto
Corcione, Silvia
De Rosa, Francesco Giuseppe
Benedetto, Chiara
D’Avolio, Antonio
Cusato, Jessica
Pregnancy and COVID-19: The Possible Contribution of Vitamin D
title Pregnancy and COVID-19: The Possible Contribution of Vitamin D
title_full Pregnancy and COVID-19: The Possible Contribution of Vitamin D
title_fullStr Pregnancy and COVID-19: The Possible Contribution of Vitamin D
title_full_unstemmed Pregnancy and COVID-19: The Possible Contribution of Vitamin D
title_short Pregnancy and COVID-19: The Possible Contribution of Vitamin D
title_sort pregnancy and covid-19: the possible contribution of vitamin d
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414046/
https://www.ncbi.nlm.nih.gov/pubmed/36014781
http://dx.doi.org/10.3390/nu14163275
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