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Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents
This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students aged 13–18 years from two schools, who received the second dose of the BNT162b2 mR...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414075/ https://www.ncbi.nlm.nih.gov/pubmed/36006288 http://dx.doi.org/10.3390/tropicalmed7080196 |
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author | Mansanguan, Suyanee Charunwatthana, Prakaykaew Piyaphanee, Watcharapong Dechkhajorn, Wilanee Poolcharoen, Akkapon Mansanguan, Chayasin |
author_facet | Mansanguan, Suyanee Charunwatthana, Prakaykaew Piyaphanee, Watcharapong Dechkhajorn, Wilanee Poolcharoen, Akkapon Mansanguan, Chayasin |
author_sort | Mansanguan, Suyanee |
collection | PubMed |
description | This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students aged 13–18 years from two schools, who received the second dose of the BNT162b2 mRNA COVID-19 vaccine. Data including demographics, symptoms, vital signs, ECG, echocardiography, and cardiac enzymes were collected at baseline, Day 3, Day 7, and Day 14 (optional) using case record forms. We enrolled 314 participants; of these, 13 participants were lost to follow-up, leaving 301 participants for analysis. The most common cardiovascular signs and symptoms were tachycardia (7.64%), shortness of breath (6.64%), palpitation (4.32%), chest pain (4.32%), and hypertension (3.99%). One participant could have more than one sign and/or symptom. Seven participants (2.33%) exhibited at least one elevated cardiac biomarker or positive lab assessments. Cardiovascular manifestations were found in 29.24% of patients, ranging from tachycardia or palpitation to myopericarditis. Myopericarditis was confirmed in one patient after vaccination. Two patients had suspected pericarditis and four patients had suspected subclinical myocarditis. In conclusion, Cardiovascular manifestation in adolescents after BNT162b2 mRNA COVID-19 vaccination included tachycardia, palpitation, and myopericarditis. The clinical presentation of myopericarditis after vaccination was usually mild and temporary, with all cases fully recovering within 14 days. Hence, adolescents receiving mRNA vaccines should be monitored for cardiovascular side effects. Clinical Trial Registration: NCT05288231. |
format | Online Article Text |
id | pubmed-9414075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94140752022-08-27 Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents Mansanguan, Suyanee Charunwatthana, Prakaykaew Piyaphanee, Watcharapong Dechkhajorn, Wilanee Poolcharoen, Akkapon Mansanguan, Chayasin Trop Med Infect Dis Article This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students aged 13–18 years from two schools, who received the second dose of the BNT162b2 mRNA COVID-19 vaccine. Data including demographics, symptoms, vital signs, ECG, echocardiography, and cardiac enzymes were collected at baseline, Day 3, Day 7, and Day 14 (optional) using case record forms. We enrolled 314 participants; of these, 13 participants were lost to follow-up, leaving 301 participants for analysis. The most common cardiovascular signs and symptoms were tachycardia (7.64%), shortness of breath (6.64%), palpitation (4.32%), chest pain (4.32%), and hypertension (3.99%). One participant could have more than one sign and/or symptom. Seven participants (2.33%) exhibited at least one elevated cardiac biomarker or positive lab assessments. Cardiovascular manifestations were found in 29.24% of patients, ranging from tachycardia or palpitation to myopericarditis. Myopericarditis was confirmed in one patient after vaccination. Two patients had suspected pericarditis and four patients had suspected subclinical myocarditis. In conclusion, Cardiovascular manifestation in adolescents after BNT162b2 mRNA COVID-19 vaccination included tachycardia, palpitation, and myopericarditis. The clinical presentation of myopericarditis after vaccination was usually mild and temporary, with all cases fully recovering within 14 days. Hence, adolescents receiving mRNA vaccines should be monitored for cardiovascular side effects. Clinical Trial Registration: NCT05288231. MDPI 2022-08-19 /pmc/articles/PMC9414075/ /pubmed/36006288 http://dx.doi.org/10.3390/tropicalmed7080196 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mansanguan, Suyanee Charunwatthana, Prakaykaew Piyaphanee, Watcharapong Dechkhajorn, Wilanee Poolcharoen, Akkapon Mansanguan, Chayasin Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents |
title | Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents |
title_full | Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents |
title_fullStr | Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents |
title_full_unstemmed | Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents |
title_short | Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents |
title_sort | cardiovascular manifestation of the bnt162b2 mrna covid-19 vaccine in adolescents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414075/ https://www.ncbi.nlm.nih.gov/pubmed/36006288 http://dx.doi.org/10.3390/tropicalmed7080196 |
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