Cargando…

Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds

Cutaneous leishmaniasis (CL) lesions are chronic and result in disfiguring scars. The microbiological aspects of these wounds have not been systematically investigated. We have recently reported that 61.5% of CL wounds in a Sri Lankan cohort harboured bacterial biofilms, mainly composed of bacilli,...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaluarachchi, T. D. Jayasena, Campbell, Paul M., Wickremasinghe, Renu, Ranasinghe, Shalindra, Yasewardene, Surangi, De Silva, Hiromel, McBain, Andrew J., Weerasekera, Manjula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414163/
https://www.ncbi.nlm.nih.gov/pubmed/36028889
http://dx.doi.org/10.1186/s41182-022-00455-y
_version_ 1784775924395278336
author Kaluarachchi, T. D. Jayasena
Campbell, Paul M.
Wickremasinghe, Renu
Ranasinghe, Shalindra
Yasewardene, Surangi
De Silva, Hiromel
McBain, Andrew J.
Weerasekera, Manjula
author_facet Kaluarachchi, T. D. Jayasena
Campbell, Paul M.
Wickremasinghe, Renu
Ranasinghe, Shalindra
Yasewardene, Surangi
De Silva, Hiromel
McBain, Andrew J.
Weerasekera, Manjula
author_sort Kaluarachchi, T. D. Jayasena
collection PubMed
description Cutaneous leishmaniasis (CL) lesions are chronic and result in disfiguring scars. The microbiological aspects of these wounds have not been systematically investigated. We have recently reported that 61.5% of CL wounds in a Sri Lankan cohort harboured bacterial biofilms, mainly composed of bacilli, Enterobacteriaceae, and Pseudomonas, which could delay wound healing. We have additionally reported that biofilms were significantly associated patients over 40 years of age, discharge, pain and/or itching of the wound, and high pus cell counts. Using this as background knowledge and other relevant literature, we highlight the importance of investigating the role of biofilms in CL wound healing, clinical indicators, cost-effective laboratory tests involving less invasive sampling techniques for diagnosing biofilms and potential therapeutic options for biofilm-containing CL wounds, such as adjunctive application of wound debridement and antimicrobial treatment along with anti-parasitic drugs.
format Online
Article
Text
id pubmed-9414163
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-94141632022-08-27 Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds Kaluarachchi, T. D. Jayasena Campbell, Paul M. Wickremasinghe, Renu Ranasinghe, Shalindra Yasewardene, Surangi De Silva, Hiromel McBain, Andrew J. Weerasekera, Manjula Trop Med Health Short Report Cutaneous leishmaniasis (CL) lesions are chronic and result in disfiguring scars. The microbiological aspects of these wounds have not been systematically investigated. We have recently reported that 61.5% of CL wounds in a Sri Lankan cohort harboured bacterial biofilms, mainly composed of bacilli, Enterobacteriaceae, and Pseudomonas, which could delay wound healing. We have additionally reported that biofilms were significantly associated patients over 40 years of age, discharge, pain and/or itching of the wound, and high pus cell counts. Using this as background knowledge and other relevant literature, we highlight the importance of investigating the role of biofilms in CL wound healing, clinical indicators, cost-effective laboratory tests involving less invasive sampling techniques for diagnosing biofilms and potential therapeutic options for biofilm-containing CL wounds, such as adjunctive application of wound debridement and antimicrobial treatment along with anti-parasitic drugs. BioMed Central 2022-08-26 /pmc/articles/PMC9414163/ /pubmed/36028889 http://dx.doi.org/10.1186/s41182-022-00455-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Report
Kaluarachchi, T. D. Jayasena
Campbell, Paul M.
Wickremasinghe, Renu
Ranasinghe, Shalindra
Yasewardene, Surangi
De Silva, Hiromel
McBain, Andrew J.
Weerasekera, Manjula
Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds
title Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds
title_full Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds
title_fullStr Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds
title_full_unstemmed Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds
title_short Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds
title_sort possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414163/
https://www.ncbi.nlm.nih.gov/pubmed/36028889
http://dx.doi.org/10.1186/s41182-022-00455-y
work_keys_str_mv AT kaluarachchitdjayasena possibleclinicalimplicationsandfuturedirectionsofmanagingbacterialbiofilmsincutaneousleishmaniasiswounds
AT campbellpaulm possibleclinicalimplicationsandfuturedirectionsofmanagingbacterialbiofilmsincutaneousleishmaniasiswounds
AT wickremasingherenu possibleclinicalimplicationsandfuturedirectionsofmanagingbacterialbiofilmsincutaneousleishmaniasiswounds
AT ranasingheshalindra possibleclinicalimplicationsandfuturedirectionsofmanagingbacterialbiofilmsincutaneousleishmaniasiswounds
AT yasewardenesurangi possibleclinicalimplicationsandfuturedirectionsofmanagingbacterialbiofilmsincutaneousleishmaniasiswounds
AT desilvahiromel possibleclinicalimplicationsandfuturedirectionsofmanagingbacterialbiofilmsincutaneousleishmaniasiswounds
AT mcbainandrewj possibleclinicalimplicationsandfuturedirectionsofmanagingbacterialbiofilmsincutaneousleishmaniasiswounds
AT weerasekeramanjula possibleclinicalimplicationsandfuturedirectionsofmanagingbacterialbiofilmsincutaneousleishmaniasiswounds