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Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. Flaviviridae nonstructural proteins, apart from their canonical roles in viral replication, have noncanonical functions strongly affe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414172/ https://www.ncbi.nlm.nih.gov/pubmed/36016430 http://dx.doi.org/10.3390/v14081808 |
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author | Latanova, Anastasia Starodubova, Elizaveta Karpov, Vadim |
author_facet | Latanova, Anastasia Starodubova, Elizaveta Karpov, Vadim |
author_sort | Latanova, Anastasia |
collection | PubMed |
description | Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. Flaviviridae nonstructural proteins, apart from their canonical roles in viral replication, have noncanonical functions strongly affecting antiviral innate immunity. Among these functions, antagonism of type I IFN is the most investigated; meanwhile, more data are accumulated on their role in the other pathways of innate response. This review systematizes the last known data on the role of Flaviviridae nonstructural proteins in molecular mechanisms of triggering inflammation, with an emphasis on their interactions with TLRs and RLRs, interference with NF-κB and cGAS-STING signaling, and activation of inflammasomes. |
format | Online Article Text |
id | pubmed-9414172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94141722022-08-27 Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation Latanova, Anastasia Starodubova, Elizaveta Karpov, Vadim Viruses Review Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. Flaviviridae nonstructural proteins, apart from their canonical roles in viral replication, have noncanonical functions strongly affecting antiviral innate immunity. Among these functions, antagonism of type I IFN is the most investigated; meanwhile, more data are accumulated on their role in the other pathways of innate response. This review systematizes the last known data on the role of Flaviviridae nonstructural proteins in molecular mechanisms of triggering inflammation, with an emphasis on their interactions with TLRs and RLRs, interference with NF-κB and cGAS-STING signaling, and activation of inflammasomes. MDPI 2022-08-18 /pmc/articles/PMC9414172/ /pubmed/36016430 http://dx.doi.org/10.3390/v14081808 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Latanova, Anastasia Starodubova, Elizaveta Karpov, Vadim Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation |
title | Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation |
title_full | Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation |
title_fullStr | Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation |
title_full_unstemmed | Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation |
title_short | Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation |
title_sort | flaviviridae nonstructural proteins: the role in molecular mechanisms of triggering inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414172/ https://www.ncbi.nlm.nih.gov/pubmed/36016430 http://dx.doi.org/10.3390/v14081808 |
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