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Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation

Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. Flaviviridae nonstructural proteins, apart from their canonical roles in viral replication, have noncanonical functions strongly affe...

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Detalles Bibliográficos
Autores principales: Latanova, Anastasia, Starodubova, Elizaveta, Karpov, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414172/
https://www.ncbi.nlm.nih.gov/pubmed/36016430
http://dx.doi.org/10.3390/v14081808
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author Latanova, Anastasia
Starodubova, Elizaveta
Karpov, Vadim
author_facet Latanova, Anastasia
Starodubova, Elizaveta
Karpov, Vadim
author_sort Latanova, Anastasia
collection PubMed
description Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. Flaviviridae nonstructural proteins, apart from their canonical roles in viral replication, have noncanonical functions strongly affecting antiviral innate immunity. Among these functions, antagonism of type I IFN is the most investigated; meanwhile, more data are accumulated on their role in the other pathways of innate response. This review systematizes the last known data on the role of Flaviviridae nonstructural proteins in molecular mechanisms of triggering inflammation, with an emphasis on their interactions with TLRs and RLRs, interference with NF-κB and cGAS-STING signaling, and activation of inflammasomes.
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spelling pubmed-94141722022-08-27 Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation Latanova, Anastasia Starodubova, Elizaveta Karpov, Vadim Viruses Review Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. Flaviviridae nonstructural proteins, apart from their canonical roles in viral replication, have noncanonical functions strongly affecting antiviral innate immunity. Among these functions, antagonism of type I IFN is the most investigated; meanwhile, more data are accumulated on their role in the other pathways of innate response. This review systematizes the last known data on the role of Flaviviridae nonstructural proteins in molecular mechanisms of triggering inflammation, with an emphasis on their interactions with TLRs and RLRs, interference with NF-κB and cGAS-STING signaling, and activation of inflammasomes. MDPI 2022-08-18 /pmc/articles/PMC9414172/ /pubmed/36016430 http://dx.doi.org/10.3390/v14081808 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Latanova, Anastasia
Starodubova, Elizaveta
Karpov, Vadim
Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
title Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
title_full Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
title_fullStr Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
title_full_unstemmed Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
title_short Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
title_sort flaviviridae nonstructural proteins: the role in molecular mechanisms of triggering inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414172/
https://www.ncbi.nlm.nih.gov/pubmed/36016430
http://dx.doi.org/10.3390/v14081808
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