Cargando…

Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance

The emergence of bacterial resistance has motivated researchers to discover new antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential classes of antibacterial agents. The new generations of fluoroquinolones are valuable therapeutic tools with a spectrum of activi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lungu, Ioana-Andreea, Moldovan, Octavia-Laura, Biriș, Victoria, Rusu, Aura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414178/
https://www.ncbi.nlm.nih.gov/pubmed/36015376
http://dx.doi.org/10.3390/pharmaceutics14081749
_version_ 1784775927976165376
author Lungu, Ioana-Andreea
Moldovan, Octavia-Laura
Biriș, Victoria
Rusu, Aura
author_facet Lungu, Ioana-Andreea
Moldovan, Octavia-Laura
Biriș, Victoria
Rusu, Aura
author_sort Lungu, Ioana-Andreea
collection PubMed
description The emergence of bacterial resistance has motivated researchers to discover new antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential classes of antibacterial agents. The new generations of fluoroquinolones are valuable therapeutic tools with a spectrum of activity, including Gram-positive, Gram-negative, and atypical bacteria. This review article surveys the design of fluoroquinolone hybrids with other antibacterial agents or active compounds and underlines the new hybrids’ antibacterial properties. Antibiotic fluoroquinolone hybrids have several advantages over combined antibiotic therapy. Thus, some challenges related to joining two different molecules are under study. Structurally, the obtained hybrids may contain a cleavable or non-cleavable linker, an essential element for their pharmacokinetic properties and mechanism of action. The design of hybrids seems to provide promising antibacterial agents helpful in the fight against more virulent and resistant strains. These hybrid structures have proven superior antibacterial activity and less susceptibility to bacterial resistance than the component molecules. In addition, fluoroquinolone hybrids have demonstrated other biological effects such as anti-HIV, antifungal, antiplasmodic/antimalarial, and antitumor activity. Many fluoroquinolone hybrids are in various phases of clinical trials, raising hopes that new antibacterial agents will be approved shortly.
format Online
Article
Text
id pubmed-9414178
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94141782022-08-27 Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance Lungu, Ioana-Andreea Moldovan, Octavia-Laura Biriș, Victoria Rusu, Aura Pharmaceutics Review The emergence of bacterial resistance has motivated researchers to discover new antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential classes of antibacterial agents. The new generations of fluoroquinolones are valuable therapeutic tools with a spectrum of activity, including Gram-positive, Gram-negative, and atypical bacteria. This review article surveys the design of fluoroquinolone hybrids with other antibacterial agents or active compounds and underlines the new hybrids’ antibacterial properties. Antibiotic fluoroquinolone hybrids have several advantages over combined antibiotic therapy. Thus, some challenges related to joining two different molecules are under study. Structurally, the obtained hybrids may contain a cleavable or non-cleavable linker, an essential element for their pharmacokinetic properties and mechanism of action. The design of hybrids seems to provide promising antibacterial agents helpful in the fight against more virulent and resistant strains. These hybrid structures have proven superior antibacterial activity and less susceptibility to bacterial resistance than the component molecules. In addition, fluoroquinolone hybrids have demonstrated other biological effects such as anti-HIV, antifungal, antiplasmodic/antimalarial, and antitumor activity. Many fluoroquinolone hybrids are in various phases of clinical trials, raising hopes that new antibacterial agents will be approved shortly. MDPI 2022-08-22 /pmc/articles/PMC9414178/ /pubmed/36015376 http://dx.doi.org/10.3390/pharmaceutics14081749 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lungu, Ioana-Andreea
Moldovan, Octavia-Laura
Biriș, Victoria
Rusu, Aura
Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance
title Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance
title_full Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance
title_fullStr Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance
title_full_unstemmed Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance
title_short Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance
title_sort fluoroquinolones hybrid molecules as promising antibacterial agents in the fight against antibacterial resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414178/
https://www.ncbi.nlm.nih.gov/pubmed/36015376
http://dx.doi.org/10.3390/pharmaceutics14081749
work_keys_str_mv AT lunguioanaandreea fluoroquinoloneshybridmoleculesaspromisingantibacterialagentsinthefightagainstantibacterialresistance
AT moldovanoctavialaura fluoroquinoloneshybridmoleculesaspromisingantibacterialagentsinthefightagainstantibacterialresistance
AT birisvictoria fluoroquinoloneshybridmoleculesaspromisingantibacterialagentsinthefightagainstantibacterialresistance
AT rusuaura fluoroquinoloneshybridmoleculesaspromisingantibacterialagentsinthefightagainstantibacterialresistance