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In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion
Restoring sensation after injury or disease requires a reproducible method for generating large quantities of bona fide somatosensory interneurons. Toward this goal, we assess the mechanisms by which dorsal spinal interneurons (dIs; dI1–dI6) can be derived from mouse embryonic stem cells (mESCs). Us...
Autores principales: | Gupta, Sandeep, Kawaguchi, Riki, Heinrichs, Eric, Gallardo, Salena, Castellanos, Stephanie, Mandric, Igor, Novitch, Bennett G., Butler, Samantha J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414195/ https://www.ncbi.nlm.nih.gov/pubmed/35858555 http://dx.doi.org/10.1016/j.celrep.2022.111119 |
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