Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their...

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Detalles Bibliográficos
Autores principales: Ramírez-Morales, Maria Antonieta, Goldt, Anastasia E., Kalachikova, Polina M., Ramirez B., Javier A., Suzuki, Masashi, Zhigach, Alexey N., Ben Salah, Asma, Shurygina, Liliya I., Shandakov, Sergey D., Zatsepin, Timofei, Krasnikov, Dmitry V., Maekawa, Toru, Nikolaev, Evgeny N., Nasibulin, Albert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414223/
https://www.ncbi.nlm.nih.gov/pubmed/36014734
http://dx.doi.org/10.3390/nano12162869
Descripción
Sumario:Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

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