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Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation

Facilitated endogenous tissue engineering, as a facile and effective strategy, is emerging for use in bone tissue regeneration. However, the development of bioactive scaffolds with excellent osteo-inductivity to recruit endogenous stem cells homing and differentiation towards lesion areas remains an...

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Autores principales: Zhao, Yao, Zhao, Sinuo, Ma, Zhengxin, Ding, Chunmei, Chen, Jingdi, Li, Jianshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414235/
https://www.ncbi.nlm.nih.gov/pubmed/36015171
http://dx.doi.org/10.3390/ph15081023
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author Zhao, Yao
Zhao, Sinuo
Ma, Zhengxin
Ding, Chunmei
Chen, Jingdi
Li, Jianshu
author_facet Zhao, Yao
Zhao, Sinuo
Ma, Zhengxin
Ding, Chunmei
Chen, Jingdi
Li, Jianshu
author_sort Zhao, Yao
collection PubMed
description Facilitated endogenous tissue engineering, as a facile and effective strategy, is emerging for use in bone tissue regeneration. However, the development of bioactive scaffolds with excellent osteo-inductivity to recruit endogenous stem cells homing and differentiation towards lesion areas remains an urgent problem. Chitosan (CS), with versatile qualities including good biocompatibility, biodegradability, and tunable physicochemical and biological properties is undergoing vigorously development in the field of bone repair. Based on this, the review focus on recent advances in chitosan-based scaffolds for facilitated endogenous bone regeneration. Initially, we introduced and compared the facilitated endogenous tissue engineering with traditional tissue engineering. Subsequently, the various CS-based bone repair scaffolds and their fabrication methods were briefly explored. Furthermore, the functional design of CS-based scaffolds in bone endogenous regeneration including biomolecular loading, inorganic nanomaterials hybridization, and physical stimulation was highlighted and discussed. Finally, the major challenges and further research directions of CS-based scaffolds were also elaborated. We hope that this review will provide valuable reference for further bone repair research in the future.
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spelling pubmed-94142352022-08-27 Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation Zhao, Yao Zhao, Sinuo Ma, Zhengxin Ding, Chunmei Chen, Jingdi Li, Jianshu Pharmaceuticals (Basel) Review Facilitated endogenous tissue engineering, as a facile and effective strategy, is emerging for use in bone tissue regeneration. However, the development of bioactive scaffolds with excellent osteo-inductivity to recruit endogenous stem cells homing and differentiation towards lesion areas remains an urgent problem. Chitosan (CS), with versatile qualities including good biocompatibility, biodegradability, and tunable physicochemical and biological properties is undergoing vigorously development in the field of bone repair. Based on this, the review focus on recent advances in chitosan-based scaffolds for facilitated endogenous bone regeneration. Initially, we introduced and compared the facilitated endogenous tissue engineering with traditional tissue engineering. Subsequently, the various CS-based bone repair scaffolds and their fabrication methods were briefly explored. Furthermore, the functional design of CS-based scaffolds in bone endogenous regeneration including biomolecular loading, inorganic nanomaterials hybridization, and physical stimulation was highlighted and discussed. Finally, the major challenges and further research directions of CS-based scaffolds were also elaborated. We hope that this review will provide valuable reference for further bone repair research in the future. MDPI 2022-08-19 /pmc/articles/PMC9414235/ /pubmed/36015171 http://dx.doi.org/10.3390/ph15081023 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Yao
Zhao, Sinuo
Ma, Zhengxin
Ding, Chunmei
Chen, Jingdi
Li, Jianshu
Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation
title Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation
title_full Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation
title_fullStr Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation
title_full_unstemmed Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation
title_short Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation
title_sort chitosan-based scaffolds for facilitated endogenous bone re-generation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414235/
https://www.ncbi.nlm.nih.gov/pubmed/36015171
http://dx.doi.org/10.3390/ph15081023
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