The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells

Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly expressed on tumor-associated myeloid cells and promotes their suppressive phenotype. However, the ligand that engages ILT3 within the tumor mi...

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Detalles Bibliográficos
Autores principales: Paavola, Kevin J., Roda, Julie M., Lin, Vicky Y., Chen, Peirong, O'Hollaren, Kyle P., Ventura, Richard, Crawley, Suzanne C., Li, Betty, Chen, Hung-I H., Malmersjö, Seth, Sharkov, Nikolai A., Horner, Geoffrey, Guo, Wei, Kutach, Alan K., Mondal, Kalyani, Zhang, Zhen, Lichtman, Joshua S., Song, Christina, Rivera, Lee B., Liu, Wenhui, Luo, Jian, Wang, Yan, Solloway, Mark J., Allan, Bernard B., Kekatpure, Avantika, Starck, Shelley R., Haldankar, Raj, Fan, Bin, Chu, Chun, Tang, Jie, Molgora, Martina, Colonna, Marco, Kaplan, Daniel D., Hsu, Jer-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414285/
https://www.ncbi.nlm.nih.gov/pubmed/34426457
http://dx.doi.org/10.1158/2326-6066.CIR-21-0240

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