Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity

The repression of repetitive elements is an important facet of p53's function as a guardian of the genome. Paradoxically, we found that p53 activated by MDM2 inhibitors induced the expression of endogenous retroviruses (ERV) via increased occupancy on ERV promoters and inhibition of two major E...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaolei, Singh, Madhurendra, Sanz Santos, Gema, Guerlavais, Vincent, Carvajal, Luis A., Aivado, Manuel, Zhan, Yue, Oliveira, Mariana M.S., Westerberg, Lisa S., Annis, D. Allen, Johnsen, John Inge, Selivanova, Galina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414294/
https://www.ncbi.nlm.nih.gov/pubmed/34230007
http://dx.doi.org/10.1158/2159-8290.CD-20-1741

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