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CIGB-300 Peptide Targets the CK2 Phospho-Acceptor Domain on Human Papillomavirus E7 and Disrupts the Retinoblastoma (RB) Complex in Cervical Cancer Cells

CIGB-300 is a clinical-grade anti-Protein Kinase CK2 peptide, binding both its substrate’s phospho-acceptor site and the CK2α catalytic subunit. The cyclic p15 inhibitory domain of CIGB-300 was initially selected in a phage display library screen for its ability to bind the CK2 phospho-acceptor doma...

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Detalles Bibliográficos
Autores principales:	Ramón, Ailyn C., Basukala, Om, Massimi, Paola, Thomas, Miranda, Perera, Yasser, Banks, Lawrence., Perea, Silvio E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414295/ https://www.ncbi.nlm.nih.gov/pubmed/36016303 http://dx.doi.org/10.3390/v14081681

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