B7-H3 Suppresses Antitumor Immunity via the CCL2–CCR2–M2 Macrophage Axis and Contributes to Ovarian Cancer Progression

New approaches beyond PD-1/PD-L1 inhibition are required to target the immunologically diverse tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC). In this study, we explored the immunosuppressive effect of B7-H3 (CD276) via the CCL2–CCR2–M2 macrophage axis and its potential as...

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Detalles Bibliográficos
Autores principales: Miyamoto, Taito, Murakami, Ryusuke, Hamanishi, Junzo, Tanigaki, Kenji, Hosoe, Yuko, Mise, Nathan, Takamatsu, Shiro, Mise, Yuka, Ukita, Masayo, Taki, Mana, Yamanoi, Koji, Horikawa, Naoki, Abiko, Kaoru, Yamaguchi, Ken, Baba, Tsukasa, Matsumura, Noriomi, Mandai, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414298/
https://www.ncbi.nlm.nih.gov/pubmed/34799346
http://dx.doi.org/10.1158/2326-6066.CIR-21-0407

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