Remodeling Chondroitin-6-Sulfate–Mediated Immune Exclusion Enhances Anti–PD-1 Response in Colorectal Cancer with Microsatellite Stability

Metastatic microsatellite-stable (MSS) colorectal cancer rarely responds to immune checkpoint inhibitors (ICI). Metabolism heterogeneity in the tumor microenvironment (TME) presents obstacles to antitumor immune response. Combining transcriptome (The Cancer Genome Atlas MSS colorectal cancer, n = 38...

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Detalles Bibliográficos
Autores principales: Wu, Qijing, Huang, Qiong, Jiang, Yu, Sun, Fei, Liang, Bishan, Wang, Jiao, Hu, Xingbin, Sun, Mengting, Ma, Zhenfeng, Shi, Yulu, Liang, Yanxiao, Tan, Yujing, Zeng, Dongqiang, Yao, Fangzhen, Xu, Xin, Yao, Zhiqi, Li, Shaowei, Rong, Xiaoxiang, Huang, Na, Sun, Li, Liao, Wangjun, Shi, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414301/
https://www.ncbi.nlm.nih.gov/pubmed/34933913
http://dx.doi.org/10.1158/2326-6066.CIR-21-0124

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