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Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone

The cytochrome P450 2D6 (CYP2D6) genotype is the single most important determinant of CYP2D6 activity as well as interindividual and interpopulation variability in CYP2D6 activity. Here, the CYP2D6 activity score provides an established tool to categorize the large number of CYP2D6 alleles by activi...

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Detalles Bibliográficos
Autores principales:	Rüdesheim, Simeon, Selzer, Dominik, Mürdter, Thomas, Igel, Svitlana, Kerb, Reinhold, Schwab, Matthias, Lehr, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414337/ https://www.ncbi.nlm.nih.gov/pubmed/36015360 http://dx.doi.org/10.3390/pharmaceutics14081734

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