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Detoxification Response of Pseudomonas fluorescens MFAF76a to Gaseous Pollutants NO(2) and NO
Bacteria are often exposed to nitrosative stress from their environment, from atmospheric pollution or from the defense mechanisms of other organisms. Reactive nitrogen species (RNS), which mediate nitrosative stress, are notably involved in the mammalian immune response through the production of ni...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414441/ https://www.ncbi.nlm.nih.gov/pubmed/36013994 http://dx.doi.org/10.3390/microorganisms10081576 |
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author | Chautrand, Thibault Depayras, Ségolène Souak, Djouhar Bouteiller, Mathilde Kondakova, Tatiana Barreau, Magalie Ben Mlouka, Mohamed Amine Hardouin, Julie Konto-Ghiorghi, Yoan Chevalier, Sylvie Merieau, Annabelle Orange, Nicole Duclairoir-Poc, Cécile |
author_facet | Chautrand, Thibault Depayras, Ségolène Souak, Djouhar Bouteiller, Mathilde Kondakova, Tatiana Barreau, Magalie Ben Mlouka, Mohamed Amine Hardouin, Julie Konto-Ghiorghi, Yoan Chevalier, Sylvie Merieau, Annabelle Orange, Nicole Duclairoir-Poc, Cécile |
author_sort | Chautrand, Thibault |
collection | PubMed |
description | Bacteria are often exposed to nitrosative stress from their environment, from atmospheric pollution or from the defense mechanisms of other organisms. Reactive nitrogen species (RNS), which mediate nitrosative stress, are notably involved in the mammalian immune response through the production of nitric oxide (NO) by the inducible NO synthase iNOS. RNS are highly reactive and can alter various biomolecules such as lipids, proteins and DNA, making them toxic for biological organisms. Resistance to RNS is therefore important for the survival of bacteria in various environments, and notably to successfully infect their host. The fuel combustion processes used in industries and transports are responsible for the emission of important quantities of two major RNS, NO and the more toxic nitrogen dioxide (NO(2)). Human exposure to NO(2) is notably linked to increases in lung infections. While the response of bacteria to NO in liquid medium is well-studied, few data are available on their exposure to gaseous NO and NO(2). This study showed that NO(2) is much more toxic than NO at similar concentrations for the airborne bacterial strain Pseudomonas fluorescens MFAF76a. The response to NO(2) involves a wide array of effectors, while the response to NO seemingly focuses on the Hmp flavohemoprotein. Results showed that NO(2) induces the production of other RNS, unlike NO, which could explain the differences between the effects of these two molecules. |
format | Online Article Text |
id | pubmed-9414441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94144412022-08-27 Detoxification Response of Pseudomonas fluorescens MFAF76a to Gaseous Pollutants NO(2) and NO Chautrand, Thibault Depayras, Ségolène Souak, Djouhar Bouteiller, Mathilde Kondakova, Tatiana Barreau, Magalie Ben Mlouka, Mohamed Amine Hardouin, Julie Konto-Ghiorghi, Yoan Chevalier, Sylvie Merieau, Annabelle Orange, Nicole Duclairoir-Poc, Cécile Microorganisms Article Bacteria are often exposed to nitrosative stress from their environment, from atmospheric pollution or from the defense mechanisms of other organisms. Reactive nitrogen species (RNS), which mediate nitrosative stress, are notably involved in the mammalian immune response through the production of nitric oxide (NO) by the inducible NO synthase iNOS. RNS are highly reactive and can alter various biomolecules such as lipids, proteins and DNA, making them toxic for biological organisms. Resistance to RNS is therefore important for the survival of bacteria in various environments, and notably to successfully infect their host. The fuel combustion processes used in industries and transports are responsible for the emission of important quantities of two major RNS, NO and the more toxic nitrogen dioxide (NO(2)). Human exposure to NO(2) is notably linked to increases in lung infections. While the response of bacteria to NO in liquid medium is well-studied, few data are available on their exposure to gaseous NO and NO(2). This study showed that NO(2) is much more toxic than NO at similar concentrations for the airborne bacterial strain Pseudomonas fluorescens MFAF76a. The response to NO(2) involves a wide array of effectors, while the response to NO seemingly focuses on the Hmp flavohemoprotein. Results showed that NO(2) induces the production of other RNS, unlike NO, which could explain the differences between the effects of these two molecules. MDPI 2022-08-05 /pmc/articles/PMC9414441/ /pubmed/36013994 http://dx.doi.org/10.3390/microorganisms10081576 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chautrand, Thibault Depayras, Ségolène Souak, Djouhar Bouteiller, Mathilde Kondakova, Tatiana Barreau, Magalie Ben Mlouka, Mohamed Amine Hardouin, Julie Konto-Ghiorghi, Yoan Chevalier, Sylvie Merieau, Annabelle Orange, Nicole Duclairoir-Poc, Cécile Detoxification Response of Pseudomonas fluorescens MFAF76a to Gaseous Pollutants NO(2) and NO |
title | Detoxification Response of Pseudomonas fluorescens MFAF76a to Gaseous Pollutants NO(2) and NO |
title_full | Detoxification Response of Pseudomonas fluorescens MFAF76a to Gaseous Pollutants NO(2) and NO |
title_fullStr | Detoxification Response of Pseudomonas fluorescens MFAF76a to Gaseous Pollutants NO(2) and NO |
title_full_unstemmed | Detoxification Response of Pseudomonas fluorescens MFAF76a to Gaseous Pollutants NO(2) and NO |
title_short | Detoxification Response of Pseudomonas fluorescens MFAF76a to Gaseous Pollutants NO(2) and NO |
title_sort | detoxification response of pseudomonas fluorescens mfaf76a to gaseous pollutants no(2) and no |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414441/ https://www.ncbi.nlm.nih.gov/pubmed/36013994 http://dx.doi.org/10.3390/microorganisms10081576 |
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