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Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival

Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expr...

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Autores principales: Huss, Linnea, Butt, Salma Tunå, Borgquist, Signe, Elebro, Karin, Sandsveden, Malte, Manjer, Jonas, Rosendahl, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414444/
https://www.ncbi.nlm.nih.gov/pubmed/36014861
http://dx.doi.org/10.3390/nu14163353
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author Huss, Linnea
Butt, Salma Tunå
Borgquist, Signe
Elebro, Karin
Sandsveden, Malte
Manjer, Jonas
Rosendahl, Ann
author_facet Huss, Linnea
Butt, Salma Tunå
Borgquist, Signe
Elebro, Karin
Sandsveden, Malte
Manjer, Jonas
Rosendahl, Ann
author_sort Huss, Linnea
collection PubMed
description Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared to women with low levels of vitamin D (odds ratio: 0.68; 95% confidence interval: 0.41–1.13). Vitamin D levels were not found to modify the association between low VDR expression and high breast cancer mortality. To conclude, there was no statistical evidence for an association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality. Further studies are needed in order to establish the effects of vitamin D on breast cancer.
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spelling pubmed-94144442022-08-27 Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival Huss, Linnea Butt, Salma Tunå Borgquist, Signe Elebro, Karin Sandsveden, Malte Manjer, Jonas Rosendahl, Ann Nutrients Article Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared to women with low levels of vitamin D (odds ratio: 0.68; 95% confidence interval: 0.41–1.13). Vitamin D levels were not found to modify the association between low VDR expression and high breast cancer mortality. To conclude, there was no statistical evidence for an association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality. Further studies are needed in order to establish the effects of vitamin D on breast cancer. MDPI 2022-08-16 /pmc/articles/PMC9414444/ /pubmed/36014861 http://dx.doi.org/10.3390/nu14163353 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huss, Linnea
Butt, Salma Tunå
Borgquist, Signe
Elebro, Karin
Sandsveden, Malte
Manjer, Jonas
Rosendahl, Ann
Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival
title Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival
title_full Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival
title_fullStr Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival
title_full_unstemmed Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival
title_short Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival
title_sort levels of vitamin d and expression of the vitamin d receptor in relation to breast cancer risk and survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414444/
https://www.ncbi.nlm.nih.gov/pubmed/36014861
http://dx.doi.org/10.3390/nu14163353
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