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Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors

The apoptotic antiproliferative actions of our previously reported CB1 allosteric modulators 5-chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to develop and synthesise a novel series of indole-2-carboxamide derivatives 5a–k, 6a–c, and 7. Different spectroscopic methods of analysis wer...

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Detalles Bibliográficos
Autores principales:	Al-Wahaibi, Lamya H., Mostafa, Yaser A., Abdelrahman, Mostafa H., El-Bahrawy, Ali H., Trembleau, Laurent, Youssif, Bahaa G. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414584/ https://www.ncbi.nlm.nih.gov/pubmed/36015154 http://dx.doi.org/10.3390/ph15081006

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