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Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria

In response to a large outbreak of the SARS-CoV-2 Beta (B.1.351) variant in the district Schwaz, Austria, a rapid mass vaccination campaign with BNT162b2 was carried out in spring 2021, immunizing more than 70% of the adult population within one week. Subsequent analysis revealed that the mass vacci...

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Autores principales: Bánki, Zoltán, Seekircher, Lisa, Falkensammer, Barbara, Bante, David, Schäfer, Helena, Harthaller, Teresa, Kimpel, Janine, Willeit, Peter, von Laer, Dorothee, Borena, Wegene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414611/
https://www.ncbi.nlm.nih.gov/pubmed/36016265
http://dx.doi.org/10.3390/v14081642
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author Bánki, Zoltán
Seekircher, Lisa
Falkensammer, Barbara
Bante, David
Schäfer, Helena
Harthaller, Teresa
Kimpel, Janine
Willeit, Peter
von Laer, Dorothee
Borena, Wegene
author_facet Bánki, Zoltán
Seekircher, Lisa
Falkensammer, Barbara
Bante, David
Schäfer, Helena
Harthaller, Teresa
Kimpel, Janine
Willeit, Peter
von Laer, Dorothee
Borena, Wegene
author_sort Bánki, Zoltán
collection PubMed
description In response to a large outbreak of the SARS-CoV-2 Beta (B.1.351) variant in the district Schwaz, Austria, a rapid mass vaccination campaign with BNT162b2 was carried out in spring 2021, immunizing more than 70% of the adult population within one week. Subsequent analysis revealed that the mass vaccination was associated with a significant reduction in new SARS-CoV-2 infections compared to control districts. Here, we aimed to evaluate both SARS-CoV-2-specific T- and B-cell responses at 35 ± 8 and 215 ± 7 days after the second dose in 600 study subjects who participated at both time points. Overall, a robust antibody and T-cell response was measured at day 35, which waned over time. Nevertheless, all persons preserved seropositivity and T cell response could still be detected in about half of the participants at day 215. Further, antibody response correlated negatively with age; however, in persons who experienced SARS-CoV-2 infection prior to study enrolment, the serum levels of both S- and N-specific antibodies surprisingly increased with age. In contrast, there was no correlation of T cell response with age. We could not detect any sex-related difference in the immune responses. SARS-CoV-2 infections prior to study enrolment or incident infections before day 215 resulted in higher antibody levels and T cell responses at day 215 compared to study participants with no history of infection. Collectively, our data support that vaccination with BNT162b2 against COVID-19 provides a durable immune response and emphasize the usefulness of vaccination even after a natural infection.
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spelling pubmed-94146112022-08-27 Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria Bánki, Zoltán Seekircher, Lisa Falkensammer, Barbara Bante, David Schäfer, Helena Harthaller, Teresa Kimpel, Janine Willeit, Peter von Laer, Dorothee Borena, Wegene Viruses Article In response to a large outbreak of the SARS-CoV-2 Beta (B.1.351) variant in the district Schwaz, Austria, a rapid mass vaccination campaign with BNT162b2 was carried out in spring 2021, immunizing more than 70% of the adult population within one week. Subsequent analysis revealed that the mass vaccination was associated with a significant reduction in new SARS-CoV-2 infections compared to control districts. Here, we aimed to evaluate both SARS-CoV-2-specific T- and B-cell responses at 35 ± 8 and 215 ± 7 days after the second dose in 600 study subjects who participated at both time points. Overall, a robust antibody and T-cell response was measured at day 35, which waned over time. Nevertheless, all persons preserved seropositivity and T cell response could still be detected in about half of the participants at day 215. Further, antibody response correlated negatively with age; however, in persons who experienced SARS-CoV-2 infection prior to study enrolment, the serum levels of both S- and N-specific antibodies surprisingly increased with age. In contrast, there was no correlation of T cell response with age. We could not detect any sex-related difference in the immune responses. SARS-CoV-2 infections prior to study enrolment or incident infections before day 215 resulted in higher antibody levels and T cell responses at day 215 compared to study participants with no history of infection. Collectively, our data support that vaccination with BNT162b2 against COVID-19 provides a durable immune response and emphasize the usefulness of vaccination even after a natural infection. MDPI 2022-07-27 /pmc/articles/PMC9414611/ /pubmed/36016265 http://dx.doi.org/10.3390/v14081642 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bánki, Zoltán
Seekircher, Lisa
Falkensammer, Barbara
Bante, David
Schäfer, Helena
Harthaller, Teresa
Kimpel, Janine
Willeit, Peter
von Laer, Dorothee
Borena, Wegene
Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria
title Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria
title_full Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria
title_fullStr Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria
title_full_unstemmed Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria
title_short Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria
title_sort six-month follow-up of immune responses after a rapid mass vaccination against sars-cov-2 with bnt162b2 in the district of schwaz/austria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414611/
https://www.ncbi.nlm.nih.gov/pubmed/36016265
http://dx.doi.org/10.3390/v14081642
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