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Bee Venom Induces Acute Inflammation through a H(2)O(2)-Mediated System That Utilizes Superoxide Dismutase
Venoms from venomous arthropods, including bees, typically induce an immediate local inflammatory response; however, how venoms acutely elicit inflammatory response and which components induce an inflammatory response remain unknown. Moreover, the presence of superoxide dismutase (SOD3) in venom and...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414663/ https://www.ncbi.nlm.nih.gov/pubmed/36006220 http://dx.doi.org/10.3390/toxins14080558 |
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author | Lee, Kwang-Sik Kim, Bo-Yeon Park, Min-Ji Deng, Yijie Kim, Jin-Myung Kim, Yun-Hui Heo, Eun-Jee Yoon, Hyung-Joo Lee, Kyeong-Yong Choi, Yong-Soo Jin, Byung-Rae |
author_facet | Lee, Kwang-Sik Kim, Bo-Yeon Park, Min-Ji Deng, Yijie Kim, Jin-Myung Kim, Yun-Hui Heo, Eun-Jee Yoon, Hyung-Joo Lee, Kyeong-Yong Choi, Yong-Soo Jin, Byung-Rae |
author_sort | Lee, Kwang-Sik |
collection | PubMed |
description | Venoms from venomous arthropods, including bees, typically induce an immediate local inflammatory response; however, how venoms acutely elicit inflammatory response and which components induce an inflammatory response remain unknown. Moreover, the presence of superoxide dismutase (SOD3) in venom and its functional link to the acute inflammatory response has not been determined to date. Here, we confirmed that SOD3 in bee venom (bvSOD3) acts as an inducer of H(2)O(2) production to promote acute inflammatory responses. In mouse models, exogenous bvSOD3 rapidly induced H(2)O(2) overproduction through superoxides that are endogenously produced by melittin and phospholipase A(2), which then upregulated caspase-1 activation and proinflammatory molecule secretion and promoted an acute inflammatory response. We also showed that the relatively severe noxious effect of bvSOD3 elevated a type 2 immune response and bvSOD3 immunization protected against venom-induced inflammation. Our findings provide a novel view of the mechanism underlying bee venom-induced acute inflammation and offer a new approach to therapeutic treatments for bee envenoming and bee venom preparations for venom therapy/immunotherapy. |
format | Online Article Text |
id | pubmed-9414663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94146632022-08-27 Bee Venom Induces Acute Inflammation through a H(2)O(2)-Mediated System That Utilizes Superoxide Dismutase Lee, Kwang-Sik Kim, Bo-Yeon Park, Min-Ji Deng, Yijie Kim, Jin-Myung Kim, Yun-Hui Heo, Eun-Jee Yoon, Hyung-Joo Lee, Kyeong-Yong Choi, Yong-Soo Jin, Byung-Rae Toxins (Basel) Article Venoms from venomous arthropods, including bees, typically induce an immediate local inflammatory response; however, how venoms acutely elicit inflammatory response and which components induce an inflammatory response remain unknown. Moreover, the presence of superoxide dismutase (SOD3) in venom and its functional link to the acute inflammatory response has not been determined to date. Here, we confirmed that SOD3 in bee venom (bvSOD3) acts as an inducer of H(2)O(2) production to promote acute inflammatory responses. In mouse models, exogenous bvSOD3 rapidly induced H(2)O(2) overproduction through superoxides that are endogenously produced by melittin and phospholipase A(2), which then upregulated caspase-1 activation and proinflammatory molecule secretion and promoted an acute inflammatory response. We also showed that the relatively severe noxious effect of bvSOD3 elevated a type 2 immune response and bvSOD3 immunization protected against venom-induced inflammation. Our findings provide a novel view of the mechanism underlying bee venom-induced acute inflammation and offer a new approach to therapeutic treatments for bee envenoming and bee venom preparations for venom therapy/immunotherapy. MDPI 2022-08-17 /pmc/articles/PMC9414663/ /pubmed/36006220 http://dx.doi.org/10.3390/toxins14080558 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Kwang-Sik Kim, Bo-Yeon Park, Min-Ji Deng, Yijie Kim, Jin-Myung Kim, Yun-Hui Heo, Eun-Jee Yoon, Hyung-Joo Lee, Kyeong-Yong Choi, Yong-Soo Jin, Byung-Rae Bee Venom Induces Acute Inflammation through a H(2)O(2)-Mediated System That Utilizes Superoxide Dismutase |
title | Bee Venom Induces Acute Inflammation through a H(2)O(2)-Mediated System That Utilizes Superoxide Dismutase |
title_full | Bee Venom Induces Acute Inflammation through a H(2)O(2)-Mediated System That Utilizes Superoxide Dismutase |
title_fullStr | Bee Venom Induces Acute Inflammation through a H(2)O(2)-Mediated System That Utilizes Superoxide Dismutase |
title_full_unstemmed | Bee Venom Induces Acute Inflammation through a H(2)O(2)-Mediated System That Utilizes Superoxide Dismutase |
title_short | Bee Venom Induces Acute Inflammation through a H(2)O(2)-Mediated System That Utilizes Superoxide Dismutase |
title_sort | bee venom induces acute inflammation through a h(2)o(2)-mediated system that utilizes superoxide dismutase |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414663/ https://www.ncbi.nlm.nih.gov/pubmed/36006220 http://dx.doi.org/10.3390/toxins14080558 |
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