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Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence

Some 30–50% of the global population and almost 20% of the European population actually suffer from chronic pain, which presents a tremendous burden to society when this pain turns into a disability and hospitalization. Palmitoylethanolamide (PEA) has been demonstrated to improve pain in preclinical...

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Autores principales: Scuteri, Damiana, Guida, Francesca, Boccella, Serena, Palazzo, Enza, Maione, Sabatino, Rodríguez-Landa, Juan Francisco, Martínez-Mota, Lucia, Tonin, Paolo, Bagetta, Giacinto, Corasaniti, Maria Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414729/
https://www.ncbi.nlm.nih.gov/pubmed/36015298
http://dx.doi.org/10.3390/pharmaceutics14081672
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author Scuteri, Damiana
Guida, Francesca
Boccella, Serena
Palazzo, Enza
Maione, Sabatino
Rodríguez-Landa, Juan Francisco
Martínez-Mota, Lucia
Tonin, Paolo
Bagetta, Giacinto
Corasaniti, Maria Tiziana
author_facet Scuteri, Damiana
Guida, Francesca
Boccella, Serena
Palazzo, Enza
Maione, Sabatino
Rodríguez-Landa, Juan Francisco
Martínez-Mota, Lucia
Tonin, Paolo
Bagetta, Giacinto
Corasaniti, Maria Tiziana
author_sort Scuteri, Damiana
collection PubMed
description Some 30–50% of the global population and almost 20% of the European population actually suffer from chronic pain, which presents a tremendous burden to society when this pain turns into a disability and hospitalization. Palmitoylethanolamide (PEA) has been demonstrated to improve pain in preclinical contexts, but an appraisal of clinical evidence is still lacking. The present study aimed at addressing the working hypothesis for the efficacy of PEA for nociceptive musculoskeletal and neuropathic pain in the clinical setting. The systematic search, selection and analysis were performed in agreement with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 recommendations. The primary outcome was pain reduction, as measured by a pain assessment scale. The secondary outcome was improvement in quality of life and/or of parameters of function. The results obtained for a total of 933 patients demonstrate the efficacy of PEA over the control (p < 0.00001), in particular in six studies apart from the two randomized, double-blind clinical trials included. However, the results are downgraded due to the high heterogeneity of the studies (I(2) = 99%), and the funnel plot suggests publication bias. Efficacy in achieving a reduction in the need for rescue medications and improvement in functioning, neuropathic symptoms and quality of life are reported. Therefore, adequately powered randomized, double-blind clinical trials are needed to deepen the domains of efficacy of add-on therapy with PEA for chronic pain. PROSPERO registration: CRD42022314395.
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spelling pubmed-94147292022-08-27 Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence Scuteri, Damiana Guida, Francesca Boccella, Serena Palazzo, Enza Maione, Sabatino Rodríguez-Landa, Juan Francisco Martínez-Mota, Lucia Tonin, Paolo Bagetta, Giacinto Corasaniti, Maria Tiziana Pharmaceutics Systematic Review Some 30–50% of the global population and almost 20% of the European population actually suffer from chronic pain, which presents a tremendous burden to society when this pain turns into a disability and hospitalization. Palmitoylethanolamide (PEA) has been demonstrated to improve pain in preclinical contexts, but an appraisal of clinical evidence is still lacking. The present study aimed at addressing the working hypothesis for the efficacy of PEA for nociceptive musculoskeletal and neuropathic pain in the clinical setting. The systematic search, selection and analysis were performed in agreement with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 recommendations. The primary outcome was pain reduction, as measured by a pain assessment scale. The secondary outcome was improvement in quality of life and/or of parameters of function. The results obtained for a total of 933 patients demonstrate the efficacy of PEA over the control (p < 0.00001), in particular in six studies apart from the two randomized, double-blind clinical trials included. However, the results are downgraded due to the high heterogeneity of the studies (I(2) = 99%), and the funnel plot suggests publication bias. Efficacy in achieving a reduction in the need for rescue medications and improvement in functioning, neuropathic symptoms and quality of life are reported. Therefore, adequately powered randomized, double-blind clinical trials are needed to deepen the domains of efficacy of add-on therapy with PEA for chronic pain. PROSPERO registration: CRD42022314395. MDPI 2022-08-11 /pmc/articles/PMC9414729/ /pubmed/36015298 http://dx.doi.org/10.3390/pharmaceutics14081672 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Scuteri, Damiana
Guida, Francesca
Boccella, Serena
Palazzo, Enza
Maione, Sabatino
Rodríguez-Landa, Juan Francisco
Martínez-Mota, Lucia
Tonin, Paolo
Bagetta, Giacinto
Corasaniti, Maria Tiziana
Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence
title Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence
title_full Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence
title_fullStr Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence
title_full_unstemmed Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence
title_short Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence
title_sort effects of palmitoylethanolamide (pea) on nociceptive, musculoskeletal and neuropathic pain: systematic review and meta-analysis of clinical evidence
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414729/
https://www.ncbi.nlm.nih.gov/pubmed/36015298
http://dx.doi.org/10.3390/pharmaceutics14081672
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