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Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study
The risk of stroke in patients with gout is high. The effect of vaccines in lowering the stroke risk in patients with gout remains unclear. We retrospectively analyzed 23,949 patients with gout (age ≥ 55 years) from the National Health Insurance Research Database over a 12-year period. The patients...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414758/ https://www.ncbi.nlm.nih.gov/pubmed/36016166 http://dx.doi.org/10.3390/vaccines10081278 |
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author | Chen, Chun-Chao Chou, Kuan-Ting Liu, Ju-Chi Chiu, Chun-Chih Yang, Tsung-Yeh Lin, Cheng-Hsin Fang, Yu-Ann Jian, William Lei, Meng-Huan Yeh, Hsien-Tang Hsu, Min-Huei Hao, Wen-Rui |
author_facet | Chen, Chun-Chao Chou, Kuan-Ting Liu, Ju-Chi Chiu, Chun-Chih Yang, Tsung-Yeh Lin, Cheng-Hsin Fang, Yu-Ann Jian, William Lei, Meng-Huan Yeh, Hsien-Tang Hsu, Min-Huei Hao, Wen-Rui |
author_sort | Chen, Chun-Chao |
collection | PubMed |
description | The risk of stroke in patients with gout is high. The effect of vaccines in lowering the stroke risk in patients with gout remains unclear. We retrospectively analyzed 23,949 patients with gout (age ≥ 55 years) from the National Health Insurance Research Database over a 12-year period. The patients were divided into vaccinated (n = 11,649) and unvaccinated groups (n = 12,300). Overall, the vaccinated group had significantly lower risks of all stroke, hemorrhagic stroke, and ischemic stroke than the unvaccinated group (adjusted hazard ratio [aHR], 0.59 and 95% confidence interval [CI], 0.55–0.63; aHR, 0.60 and 95% CI, 0.49–0.73; and aHR, 0.60 and 95% CI, 0.55–0.65, respectively). The association appeared to be dose-dependent for both hemorrhagic and ischemic stroke (hemorrhagic stroke: aHR, 0.81 and 95% CI, 0.61–1.08; aHR, 0.80 and 95% CI, 0.62–1.02; and aHR, 0.37 and 95% CI, 0.28–0.48; ischemic stroke: aHR, 0.83 and 95% CI, 0.74–0.94; aHR, 0.73 and 95% CI, 0.65–0.81; and aHR, 0.42 and 95% CI, 0.38–0.47 for patients vaccinated 1, 2 or 3, and ≥4 times, respectively, during the follow-up period). Patients with a history of atrial fibrillation did not have a lower risk of hemorrhagic stroke even after receiving four vaccinations (aHR, 0.59; 95% CI, 0.25–1.38). Influenza vaccination was associated with a lower risk of all stroke in people with gout, and the association appeared to be dose-dependent. |
format | Online Article Text |
id | pubmed-9414758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94147582022-08-27 Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study Chen, Chun-Chao Chou, Kuan-Ting Liu, Ju-Chi Chiu, Chun-Chih Yang, Tsung-Yeh Lin, Cheng-Hsin Fang, Yu-Ann Jian, William Lei, Meng-Huan Yeh, Hsien-Tang Hsu, Min-Huei Hao, Wen-Rui Vaccines (Basel) Article The risk of stroke in patients with gout is high. The effect of vaccines in lowering the stroke risk in patients with gout remains unclear. We retrospectively analyzed 23,949 patients with gout (age ≥ 55 years) from the National Health Insurance Research Database over a 12-year period. The patients were divided into vaccinated (n = 11,649) and unvaccinated groups (n = 12,300). Overall, the vaccinated group had significantly lower risks of all stroke, hemorrhagic stroke, and ischemic stroke than the unvaccinated group (adjusted hazard ratio [aHR], 0.59 and 95% confidence interval [CI], 0.55–0.63; aHR, 0.60 and 95% CI, 0.49–0.73; and aHR, 0.60 and 95% CI, 0.55–0.65, respectively). The association appeared to be dose-dependent for both hemorrhagic and ischemic stroke (hemorrhagic stroke: aHR, 0.81 and 95% CI, 0.61–1.08; aHR, 0.80 and 95% CI, 0.62–1.02; and aHR, 0.37 and 95% CI, 0.28–0.48; ischemic stroke: aHR, 0.83 and 95% CI, 0.74–0.94; aHR, 0.73 and 95% CI, 0.65–0.81; and aHR, 0.42 and 95% CI, 0.38–0.47 for patients vaccinated 1, 2 or 3, and ≥4 times, respectively, during the follow-up period). Patients with a history of atrial fibrillation did not have a lower risk of hemorrhagic stroke even after receiving four vaccinations (aHR, 0.59; 95% CI, 0.25–1.38). Influenza vaccination was associated with a lower risk of all stroke in people with gout, and the association appeared to be dose-dependent. MDPI 2022-08-08 /pmc/articles/PMC9414758/ /pubmed/36016166 http://dx.doi.org/10.3390/vaccines10081278 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Chun-Chao Chou, Kuan-Ting Liu, Ju-Chi Chiu, Chun-Chih Yang, Tsung-Yeh Lin, Cheng-Hsin Fang, Yu-Ann Jian, William Lei, Meng-Huan Yeh, Hsien-Tang Hsu, Min-Huei Hao, Wen-Rui Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study |
title | Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study |
title_full | Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study |
title_fullStr | Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study |
title_full_unstemmed | Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study |
title_short | Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study |
title_sort | association between stroke risk and influenza vaccination in patients with gout: a nationwide population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414758/ https://www.ncbi.nlm.nih.gov/pubmed/36016166 http://dx.doi.org/10.3390/vaccines10081278 |
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