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Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study

The risk of stroke in patients with gout is high. The effect of vaccines in lowering the stroke risk in patients with gout remains unclear. We retrospectively analyzed 23,949 patients with gout (age ≥ 55 years) from the National Health Insurance Research Database over a 12-year period. The patients...

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Autores principales: Chen, Chun-Chao, Chou, Kuan-Ting, Liu, Ju-Chi, Chiu, Chun-Chih, Yang, Tsung-Yeh, Lin, Cheng-Hsin, Fang, Yu-Ann, Jian, William, Lei, Meng-Huan, Yeh, Hsien-Tang, Hsu, Min-Huei, Hao, Wen-Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414758/
https://www.ncbi.nlm.nih.gov/pubmed/36016166
http://dx.doi.org/10.3390/vaccines10081278
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author Chen, Chun-Chao
Chou, Kuan-Ting
Liu, Ju-Chi
Chiu, Chun-Chih
Yang, Tsung-Yeh
Lin, Cheng-Hsin
Fang, Yu-Ann
Jian, William
Lei, Meng-Huan
Yeh, Hsien-Tang
Hsu, Min-Huei
Hao, Wen-Rui
author_facet Chen, Chun-Chao
Chou, Kuan-Ting
Liu, Ju-Chi
Chiu, Chun-Chih
Yang, Tsung-Yeh
Lin, Cheng-Hsin
Fang, Yu-Ann
Jian, William
Lei, Meng-Huan
Yeh, Hsien-Tang
Hsu, Min-Huei
Hao, Wen-Rui
author_sort Chen, Chun-Chao
collection PubMed
description The risk of stroke in patients with gout is high. The effect of vaccines in lowering the stroke risk in patients with gout remains unclear. We retrospectively analyzed 23,949 patients with gout (age ≥ 55 years) from the National Health Insurance Research Database over a 12-year period. The patients were divided into vaccinated (n = 11,649) and unvaccinated groups (n = 12,300). Overall, the vaccinated group had significantly lower risks of all stroke, hemorrhagic stroke, and ischemic stroke than the unvaccinated group (adjusted hazard ratio [aHR], 0.59 and 95% confidence interval [CI], 0.55–0.63; aHR, 0.60 and 95% CI, 0.49–0.73; and aHR, 0.60 and 95% CI, 0.55–0.65, respectively). The association appeared to be dose-dependent for both hemorrhagic and ischemic stroke (hemorrhagic stroke: aHR, 0.81 and 95% CI, 0.61–1.08; aHR, 0.80 and 95% CI, 0.62–1.02; and aHR, 0.37 and 95% CI, 0.28–0.48; ischemic stroke: aHR, 0.83 and 95% CI, 0.74–0.94; aHR, 0.73 and 95% CI, 0.65–0.81; and aHR, 0.42 and 95% CI, 0.38–0.47 for patients vaccinated 1, 2 or 3, and ≥4 times, respectively, during the follow-up period). Patients with a history of atrial fibrillation did not have a lower risk of hemorrhagic stroke even after receiving four vaccinations (aHR, 0.59; 95% CI, 0.25–1.38). Influenza vaccination was associated with a lower risk of all stroke in people with gout, and the association appeared to be dose-dependent.
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spelling pubmed-94147582022-08-27 Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study Chen, Chun-Chao Chou, Kuan-Ting Liu, Ju-Chi Chiu, Chun-Chih Yang, Tsung-Yeh Lin, Cheng-Hsin Fang, Yu-Ann Jian, William Lei, Meng-Huan Yeh, Hsien-Tang Hsu, Min-Huei Hao, Wen-Rui Vaccines (Basel) Article The risk of stroke in patients with gout is high. The effect of vaccines in lowering the stroke risk in patients with gout remains unclear. We retrospectively analyzed 23,949 patients with gout (age ≥ 55 years) from the National Health Insurance Research Database over a 12-year period. The patients were divided into vaccinated (n = 11,649) and unvaccinated groups (n = 12,300). Overall, the vaccinated group had significantly lower risks of all stroke, hemorrhagic stroke, and ischemic stroke than the unvaccinated group (adjusted hazard ratio [aHR], 0.59 and 95% confidence interval [CI], 0.55–0.63; aHR, 0.60 and 95% CI, 0.49–0.73; and aHR, 0.60 and 95% CI, 0.55–0.65, respectively). The association appeared to be dose-dependent for both hemorrhagic and ischemic stroke (hemorrhagic stroke: aHR, 0.81 and 95% CI, 0.61–1.08; aHR, 0.80 and 95% CI, 0.62–1.02; and aHR, 0.37 and 95% CI, 0.28–0.48; ischemic stroke: aHR, 0.83 and 95% CI, 0.74–0.94; aHR, 0.73 and 95% CI, 0.65–0.81; and aHR, 0.42 and 95% CI, 0.38–0.47 for patients vaccinated 1, 2 or 3, and ≥4 times, respectively, during the follow-up period). Patients with a history of atrial fibrillation did not have a lower risk of hemorrhagic stroke even after receiving four vaccinations (aHR, 0.59; 95% CI, 0.25–1.38). Influenza vaccination was associated with a lower risk of all stroke in people with gout, and the association appeared to be dose-dependent. MDPI 2022-08-08 /pmc/articles/PMC9414758/ /pubmed/36016166 http://dx.doi.org/10.3390/vaccines10081278 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Chun-Chao
Chou, Kuan-Ting
Liu, Ju-Chi
Chiu, Chun-Chih
Yang, Tsung-Yeh
Lin, Cheng-Hsin
Fang, Yu-Ann
Jian, William
Lei, Meng-Huan
Yeh, Hsien-Tang
Hsu, Min-Huei
Hao, Wen-Rui
Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study
title Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study
title_full Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study
title_fullStr Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study
title_full_unstemmed Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study
title_short Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study
title_sort association between stroke risk and influenza vaccination in patients with gout: a nationwide population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414758/
https://www.ncbi.nlm.nih.gov/pubmed/36016166
http://dx.doi.org/10.3390/vaccines10081278
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