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The Effect of Two Different Insulin Formulations on Postprandial Hyperglycemia after High and Low Glycemic-Index Meal in Type 1 Diabetes

Despite multiple pharmacological options, including rapid-acting insulin analogs, postprandial hyperglycemia is still highly prevalent in patients with type 1 and type 2 diabetes. We hypothesize that the new rapid-acting insulin formulation, the so-called faster-acting Aspart, may have a different e...

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Autores principales: Cutruzzolà, Antonio, Parise, Martina, Fiorentino, Raffaella, Romano, Agata, Molinaro, Viviana, Gnasso, Agostino, Di Molfetta, Sergio, Irace, Concetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414780/
https://www.ncbi.nlm.nih.gov/pubmed/36014822
http://dx.doi.org/10.3390/nu14163316
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author Cutruzzolà, Antonio
Parise, Martina
Fiorentino, Raffaella
Romano, Agata
Molinaro, Viviana
Gnasso, Agostino
Di Molfetta, Sergio
Irace, Concetta
author_facet Cutruzzolà, Antonio
Parise, Martina
Fiorentino, Raffaella
Romano, Agata
Molinaro, Viviana
Gnasso, Agostino
Di Molfetta, Sergio
Irace, Concetta
author_sort Cutruzzolà, Antonio
collection PubMed
description Despite multiple pharmacological options, including rapid-acting insulin analogs, postprandial hyperglycemia is still highly prevalent in patients with type 1 and type 2 diabetes. We hypothesize that the new rapid-acting insulin formulation, the so-called faster-acting Aspart, may have a different effect in controlling postprandial hyperglycemic burden according to the quality of the meal compared to the traditional Aspart. Twenty-five patients with type 1 diabetes were consecutively recruited at the diabetes care center of the University Hospital affiliate of the Magna Græcia University of Catanzaro. Each patient performed four meal tests one week apart, two with a predefined high glycemic index (HGI) food and two with a low glycemic index (LGI) food using insulin Aspart once and Faster Aspart the other time. The 0–30 min, 0–60 min, and 0–120 min glucose Area Under the Curve (AUC) of postprandial glycemic excursion, calculated from continuous glucose monitoring data, were significantly lower with Faster Aspart administered before the HGI test meal as compared to Aspart. A significant difference in favor of Faster Aspart was also found when comparing the 0–60 min and 0–120 min AUC after the LGI meal. Faster Aspart may provide better postprandial glucose control than Aspart regardless of the glycemic index of the meal.
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spelling pubmed-94147802022-08-27 The Effect of Two Different Insulin Formulations on Postprandial Hyperglycemia after High and Low Glycemic-Index Meal in Type 1 Diabetes Cutruzzolà, Antonio Parise, Martina Fiorentino, Raffaella Romano, Agata Molinaro, Viviana Gnasso, Agostino Di Molfetta, Sergio Irace, Concetta Nutrients Article Despite multiple pharmacological options, including rapid-acting insulin analogs, postprandial hyperglycemia is still highly prevalent in patients with type 1 and type 2 diabetes. We hypothesize that the new rapid-acting insulin formulation, the so-called faster-acting Aspart, may have a different effect in controlling postprandial hyperglycemic burden according to the quality of the meal compared to the traditional Aspart. Twenty-five patients with type 1 diabetes were consecutively recruited at the diabetes care center of the University Hospital affiliate of the Magna Græcia University of Catanzaro. Each patient performed four meal tests one week apart, two with a predefined high glycemic index (HGI) food and two with a low glycemic index (LGI) food using insulin Aspart once and Faster Aspart the other time. The 0–30 min, 0–60 min, and 0–120 min glucose Area Under the Curve (AUC) of postprandial glycemic excursion, calculated from continuous glucose monitoring data, were significantly lower with Faster Aspart administered before the HGI test meal as compared to Aspart. A significant difference in favor of Faster Aspart was also found when comparing the 0–60 min and 0–120 min AUC after the LGI meal. Faster Aspart may provide better postprandial glucose control than Aspart regardless of the glycemic index of the meal. MDPI 2022-08-12 /pmc/articles/PMC9414780/ /pubmed/36014822 http://dx.doi.org/10.3390/nu14163316 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cutruzzolà, Antonio
Parise, Martina
Fiorentino, Raffaella
Romano, Agata
Molinaro, Viviana
Gnasso, Agostino
Di Molfetta, Sergio
Irace, Concetta
The Effect of Two Different Insulin Formulations on Postprandial Hyperglycemia after High and Low Glycemic-Index Meal in Type 1 Diabetes
title The Effect of Two Different Insulin Formulations on Postprandial Hyperglycemia after High and Low Glycemic-Index Meal in Type 1 Diabetes
title_full The Effect of Two Different Insulin Formulations on Postprandial Hyperglycemia after High and Low Glycemic-Index Meal in Type 1 Diabetes
title_fullStr The Effect of Two Different Insulin Formulations on Postprandial Hyperglycemia after High and Low Glycemic-Index Meal in Type 1 Diabetes
title_full_unstemmed The Effect of Two Different Insulin Formulations on Postprandial Hyperglycemia after High and Low Glycemic-Index Meal in Type 1 Diabetes
title_short The Effect of Two Different Insulin Formulations on Postprandial Hyperglycemia after High and Low Glycemic-Index Meal in Type 1 Diabetes
title_sort effect of two different insulin formulations on postprandial hyperglycemia after high and low glycemic-index meal in type 1 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414780/
https://www.ncbi.nlm.nih.gov/pubmed/36014822
http://dx.doi.org/10.3390/nu14163316
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