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Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss

The skin tissue of the scalp is unique from other skin tissues because it coexists with hair, and many differences in microbial composition have been confirmed. In scalp tissues, hair loss occurs due to a combination of internal and external factors, and several studies are being conducted to counte...

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Autores principales: Jo, HyungWoo, Kim, Seon Yu, Kang, Byung Ha, Baek, Chaeyun, Kwon, Jeong Eun, Jeang, Jin Woo, Heo, Young Mok, Kim, Hye-Been, Heo, Chan Yeong, Kang, So Min, Shin, Byung Ho, Nam, Da Yeong, Lee, Yeong-Geun, Kang, Se Chan, Lee, Dong-Geol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414784/
https://www.ncbi.nlm.nih.gov/pubmed/36014376
http://dx.doi.org/10.3390/molecules27165136
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author Jo, HyungWoo
Kim, Seon Yu
Kang, Byung Ha
Baek, Chaeyun
Kwon, Jeong Eun
Jeang, Jin Woo
Heo, Young Mok
Kim, Hye-Been
Heo, Chan Yeong
Kang, So Min
Shin, Byung Ho
Nam, Da Yeong
Lee, Yeong-Geun
Kang, Se Chan
Lee, Dong-Geol
author_facet Jo, HyungWoo
Kim, Seon Yu
Kang, Byung Ha
Baek, Chaeyun
Kwon, Jeong Eun
Jeang, Jin Woo
Heo, Young Mok
Kim, Hye-Been
Heo, Chan Yeong
Kang, So Min
Shin, Byung Ho
Nam, Da Yeong
Lee, Yeong-Geun
Kang, Se Chan
Lee, Dong-Geol
author_sort Jo, HyungWoo
collection PubMed
description The skin tissue of the scalp is unique from other skin tissues because it coexists with hair, and many differences in microbial composition have been confirmed. In scalp tissues, hair loss occurs due to a combination of internal and external factors, and several studies are being conducted to counteract this. However, not many studies have addressed hair loss from the perspective of the microbiome. In this study, subjects with hair loss and those with normal scalps were set as experimental and control groups, respectively. In the experimental group, hair loss had progressed, and there was a large difference in microbiome composition compared to the group with normal scalps. In particular, differences in Accumulibacter, Staphylococcus, and Corynebacterium were found. From Staphylococcus epidermidis Cicaria, two active components were isolated as a result of repeated column chromatography. Spectroscopic data led to the determination of chemical structures for adenosine and biotin. Fractions were obtained, and ex vivo tests were conducted using hair follicles derived from human scalp tissue. When the microbiome adenosine-treated group was compared to the control group, hair follicle length was increased, and hair root diameter was maintained during the experimental periods. In addition, the Cicaria culture medium and the microbial adenosine- and biotin-treated groups maintained the anagen phase, reducing progression to the catagen phase in the hair growth cycle. In conclusion, it was confirmed that the Cicaria culture medium and the microbial adenosine and biotin derived from the culture were effective in inhibiting hair loss.
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spelling pubmed-94147842022-08-27 Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss Jo, HyungWoo Kim, Seon Yu Kang, Byung Ha Baek, Chaeyun Kwon, Jeong Eun Jeang, Jin Woo Heo, Young Mok Kim, Hye-Been Heo, Chan Yeong Kang, So Min Shin, Byung Ho Nam, Da Yeong Lee, Yeong-Geun Kang, Se Chan Lee, Dong-Geol Molecules Article The skin tissue of the scalp is unique from other skin tissues because it coexists with hair, and many differences in microbial composition have been confirmed. In scalp tissues, hair loss occurs due to a combination of internal and external factors, and several studies are being conducted to counteract this. However, not many studies have addressed hair loss from the perspective of the microbiome. In this study, subjects with hair loss and those with normal scalps were set as experimental and control groups, respectively. In the experimental group, hair loss had progressed, and there was a large difference in microbiome composition compared to the group with normal scalps. In particular, differences in Accumulibacter, Staphylococcus, and Corynebacterium were found. From Staphylococcus epidermidis Cicaria, two active components were isolated as a result of repeated column chromatography. Spectroscopic data led to the determination of chemical structures for adenosine and biotin. Fractions were obtained, and ex vivo tests were conducted using hair follicles derived from human scalp tissue. When the microbiome adenosine-treated group was compared to the control group, hair follicle length was increased, and hair root diameter was maintained during the experimental periods. In addition, the Cicaria culture medium and the microbial adenosine- and biotin-treated groups maintained the anagen phase, reducing progression to the catagen phase in the hair growth cycle. In conclusion, it was confirmed that the Cicaria culture medium and the microbial adenosine and biotin derived from the culture were effective in inhibiting hair loss. MDPI 2022-08-12 /pmc/articles/PMC9414784/ /pubmed/36014376 http://dx.doi.org/10.3390/molecules27165136 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jo, HyungWoo
Kim, Seon Yu
Kang, Byung Ha
Baek, Chaeyun
Kwon, Jeong Eun
Jeang, Jin Woo
Heo, Young Mok
Kim, Hye-Been
Heo, Chan Yeong
Kang, So Min
Shin, Byung Ho
Nam, Da Yeong
Lee, Yeong-Geun
Kang, Se Chan
Lee, Dong-Geol
Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss
title Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss
title_full Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss
title_fullStr Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss
title_full_unstemmed Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss
title_short Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss
title_sort staphylococcus epidermidis cicaria, a novel strain derived from the human microbiome, and its efficacy as a treatment for hair loss
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414784/
https://www.ncbi.nlm.nih.gov/pubmed/36014376
http://dx.doi.org/10.3390/molecules27165136
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