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Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential

Nanotechnology is a new field that has gained considerable importance due to its potential uses in the field of biosciences, medicine, engineering, etc. In the present study, bio-inspired metallic iron nanoparticles (FeNPs) were prepared using biomass of Enterobacter train G52. The prepared particle...

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Autores principales: Zafar, Sania, Faisal, Shah, Jan, Hasnain, Ullah, Riaz, Rizwan, Muhammad, Abdullah, Alotaibi, Amal, Bibi, Nadia, Rashid, Amin Ur, Khattak, Aishma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414903/
https://www.ncbi.nlm.nih.gov/pubmed/36014181
http://dx.doi.org/10.3390/mi13081259
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author Zafar, Sania
Faisal, Shah
Jan, Hasnain
Ullah, Riaz
Rizwan, Muhammad
Abdullah,
Alotaibi, Amal
Bibi, Nadia
Rashid, Amin Ur
Khattak, Aishma
author_facet Zafar, Sania
Faisal, Shah
Jan, Hasnain
Ullah, Riaz
Rizwan, Muhammad
Abdullah,
Alotaibi, Amal
Bibi, Nadia
Rashid, Amin Ur
Khattak, Aishma
author_sort Zafar, Sania
collection PubMed
description Nanotechnology is a new field that has gained considerable importance due to its potential uses in the field of biosciences, medicine, engineering, etc. In the present study, bio-inspired metallic iron nanoparticles (FeNPs) were prepared using biomass of Enterobacter train G52. The prepared particles were characterized by UV-spectroscopy, TGA, XRD, SEM, EDX, and FTIR techniques. The crystalline nature of the prepared FeNPs was confirmed by XRD. The SEM techniques revealed the particles size to be 23 nm, whereas in FTIR spectra the peaks in the functional group region indicated the involvement of bioactive compounds of selected bacterial strains in the capping of FeNPs. The EDX confirmed the presence of iron in the engineered FeNPs. The FeNPs were then evaluated for its antibacterial, antifungal, antioxidant, anti-inflammatory, anti-Alzheimer’s, anti-larvicidal, protein kinase inhibition, anti-diabetic, and biocompatibility potentials using standard protocols. Substantial activities were observed in almost all biological assays used. The antioxidant, anti-cholinesterase, and anti-diabetic potential of the prepared nanoparticles were high in comparison to other areas of biological potential, indicating that the FeNPs are capable of targeting meditators of oxidative stress leading to diabetes and Alzheimer’s disease. However, the claim made needs some further experimentation to confirm the observed potential in in vivo animal models.
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spelling pubmed-94149032022-08-27 Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential Zafar, Sania Faisal, Shah Jan, Hasnain Ullah, Riaz Rizwan, Muhammad Abdullah, Alotaibi, Amal Bibi, Nadia Rashid, Amin Ur Khattak, Aishma Micromachines (Basel) Article Nanotechnology is a new field that has gained considerable importance due to its potential uses in the field of biosciences, medicine, engineering, etc. In the present study, bio-inspired metallic iron nanoparticles (FeNPs) were prepared using biomass of Enterobacter train G52. The prepared particles were characterized by UV-spectroscopy, TGA, XRD, SEM, EDX, and FTIR techniques. The crystalline nature of the prepared FeNPs was confirmed by XRD. The SEM techniques revealed the particles size to be 23 nm, whereas in FTIR spectra the peaks in the functional group region indicated the involvement of bioactive compounds of selected bacterial strains in the capping of FeNPs. The EDX confirmed the presence of iron in the engineered FeNPs. The FeNPs were then evaluated for its antibacterial, antifungal, antioxidant, anti-inflammatory, anti-Alzheimer’s, anti-larvicidal, protein kinase inhibition, anti-diabetic, and biocompatibility potentials using standard protocols. Substantial activities were observed in almost all biological assays used. The antioxidant, anti-cholinesterase, and anti-diabetic potential of the prepared nanoparticles were high in comparison to other areas of biological potential, indicating that the FeNPs are capable of targeting meditators of oxidative stress leading to diabetes and Alzheimer’s disease. However, the claim made needs some further experimentation to confirm the observed potential in in vivo animal models. MDPI 2022-08-05 /pmc/articles/PMC9414903/ /pubmed/36014181 http://dx.doi.org/10.3390/mi13081259 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zafar, Sania
Faisal, Shah
Jan, Hasnain
Ullah, Riaz
Rizwan, Muhammad
Abdullah,
Alotaibi, Amal
Bibi, Nadia
Rashid, Amin Ur
Khattak, Aishma
Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential
title Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential
title_full Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential
title_fullStr Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential
title_full_unstemmed Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential
title_short Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential
title_sort development of iron nanoparticles (fenps) using biomass of enterobacter: its characterization, antimicrobial, anti-alzheimer’s, and enzyme inhibition potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414903/
https://www.ncbi.nlm.nih.gov/pubmed/36014181
http://dx.doi.org/10.3390/mi13081259
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