Cargando…

Search for Novel Potent Inhibitors of the SARS-CoV-2 Papain-like Enzyme: A Computational Biochemistry Approach

The rapid emergence and spread of new variants of coronavirus type 2, as well as the emergence of zoonotic viruses, highlights the need for methodologies that contribute to the search for new pharmacological treatments. In the present work, we searched for new SARS-CoV-2 papain-like protease inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Osorio, Manuel I., Yáñez, Osvaldo, Gallardo, Mauricio, Zuñiga-Bustos, Matías, Mulia-Rodríguez, Jorge, López-Rendón, Roberto, García-Beltrán, Olimpo, González-Nilo, Fernando, Pérez-Donoso, José M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414997/ https://www.ncbi.nlm.nih.gov/pubmed/36015134 http://dx.doi.org/10.3390/ph15080986

Ejemplares similares

In Silico Study of Coumarins and Quinolines Derivatives as Potent Inhibitors of SARS-CoV-2 Main Protease
por: Yañez, Osvaldo, et al.
Publicado: (2021)

Structural Factors That Determine the Activity of the Xenobiotic Reductase B Enzyme from Pseudomonas putida on Nitroaromatic Compounds
por: Osorio, Manuel I., et al.
Publicado: (2022)

Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 protease
por: Yañez, Osvaldo, et al.
Publicado: (2021)

Theoretical Study of the Antioxidant Activity of Quercetin Oxidation Products
por: Vásquez-Espinal, Alejandro, et al.
Publicado: (2019)

Utilization of gel electrophoreses for the quantitative estimation of digestive enzyme papain
por: Muharram, Magdy M., et al.
Publicado: (2017)

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2
por: Sanders, Brian, et al.
Publicado: (2022)

Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
por: Shan, Hengyue, et al.
Publicado: (2021)

Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease
por: Li, Lingyu, et al.
Publicado: (2022)

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2
por: Sanders, Brian, et al.
Publicado: (2022)

Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
por: Sanders, Brian C., et al.
Publicado: (2023)

Biosystem Analysis of the Hypoxia Inducible Domain Family Member 2A: Implications in Cancer Biology
por: Salazar, Celia, et al.
Publicado: (2020)

STUDIES IN BLOOD COAGULATION : V. THE COAGULATION OF BLOOD BY PROTEOLYTIC ENZYMES (TRYPSIN, PAPAIN)
por: Eagle, Harry, et al.
Publicado: (1937)

Monolithic Papain-Immobilized Enzyme Reactors for Automated Structural Characterization of Monoclonal Antibodies
por: Rinaldi, Francesca, et al.
Publicado: (2021)

Increasing the Yield and Cryosurvival of Spermatozoa from Rhinoceros Ejaculates Using the Enzyme Papain
por: Rickard, Jessica P., et al.
Publicado: (2022)

THE ESTIMATION OF PAPAIN WITH HEMOGLOBIN
por: Anson, M. L.
Publicado: (1937)

Properties and Uses of Papain
Publicado: (1897)

THE REMOVAL OF CARTILAGE MATRIX BY PAPAIN : FACTORS AFFECTING THE DISTRIBUTION OF CRYSTALLINE PAPAIN IN VIVO
por: Potter, J. L., et al.
Publicado: (1960)

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities
por: Mielech, Anna M., et al.
Publicado: (2014)

Evaluation of the Effects of Bromelain and Papain Enzymes on Shear Bond Strength of Composite Resin to Enamel
por: Sharafeddin, Farahnaz, et al.
Publicado: (2021)

THE REMOVAL OF CARTILAGE MATRIX, IN VIVO, BY PAPAIN : IDENTIFICATION OF CRYSTALLINE PAPAIN PROTEASE AS THE CAUSE OF THE PHENOMENON
por: McCluskey, Robert T., et al.
Publicado: (1958)

Applicability of papain solutions in immunohematology
por: Santis, Laís Priscila De, et al.
Publicado: (2019)

Coronavirus Papain-like Peptidases
por: Ratia, Kiira, et al.
Publicado: (2013)

Coumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies
por: Moya-Alvarado, Guillermo, et al.
Publicado: (2021)

Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2
por: Weglarz-Tomczak, Ewelina, et al.
Publicado: (2021)

Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
por: Wang, Qian, et al.
Publicado: (2023)

UHPLC-MS Metabolomic Fingerprinting, Antioxidant, and Enzyme Inhibition Activities of Himantormia lugubris from Antarctica
por: Areche, Carlos, et al.
Publicado: (2022)

Immobilization of Papain on Chitin and Chitosan and Recycling of Soluble Enzyme for Deflocculation of Saccharomyces cerevisiae from Bioethanol Distilleries
por: Silva, Douglas Fernandes, et al.
Publicado: (2015)

Notes on the Use of Papaïn in Ear Diseases
por: Johnston, R. M'Kenzie
Publicado: (1890)

X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
por: Báez-Santos, Yahira M., et al.
Publicado: (2014)

Identification of potent food constituents as SARS-CoV-2 papain-like protease modulators through advanced pharmacoinformatics approaches
por: Bhowmick, Shovonlal, et al.
Publicado: (2022)

Development of Volatile Compounds during Hydrolysis of Porcine Hemoglobin with Papain
por: Bak, Kathrine Holmgaard, et al.
Publicado: (2018)

Can Biochemistry Usefully Guide the Search for Better Polymer Electrolytes?
por: Halley, J. Woods
Publicado: (2013)

PROTEOLYTIC ENZYMES : III. FURTHER STUDIES ON PROTEIN, POLYPEPTIDE, AND OTHER INHIBITORS OF SERUM PROTEINASE, LEUCOPROTEINASE, TRYPSIN, AND PAPAIN
por: Grob, David
Publicado: (1949)

Plant proteolytic enzyme papain abrogates angiogenic activation of human umbilical vein endothelial cells (HUVEC) in vitro
por: Mohr, Thomas, et al.
Publicado: (2013)

Updated ATLAS of Biochemistry with New Metabolites and Improved Enzyme Prediction Power
por: Hafner, Jasmin, et al.
Publicado: (2020)

Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors
por: Freire, Marjorie C. L. C., et al.
Publicado: (2021)

Biochemistry-informed design selects potent siRNAs against SARS-CoV-2
por: Houbron, Élisabeth, et al.
Publicado: (2023)

PAPAIN DIGESTION FRAGMENTS OF HUMAN IGM GLOBULINS
por: Mihaesco, Constantin, et al.
Publicado: (1968)

ACTION OF PAPAIN AND FICIN ON TADPOLES AND ARBACIA EGGS
por: Northrop, John H.
Publicado: (1947)

THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN
por: Anson, M. L.
Publicado: (1938)

Cannot write session to /tmp/vufind_sessions/sess_lhf9kqhd94lnrvva8bbllec6ov