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Health Benefits and Pharmacological Aspects of Chrysoeriol
A flavone, chrysoeriol is synthetized in several plant species. It comes from several natural sources, especially medicinal plants. The identification and isolation of this compound has been carried out and verified by several research teams using different spectral methods. It seems that the concen...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415049/ https://www.ncbi.nlm.nih.gov/pubmed/36015121 http://dx.doi.org/10.3390/ph15080973 |
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author | Aboulaghras, Sara Sahib, Nargis Bakrim, Saad Benali, Taoufiq Charfi, Saoulajan Guaouguaou, Fatima-Ezzahrae Omari, Nasreddine El Gallo, Monica Montesano, Domenico Zengin, Gokhan Taghzouti, Khalid Bouyahya, Abdelhakim |
author_facet | Aboulaghras, Sara Sahib, Nargis Bakrim, Saad Benali, Taoufiq Charfi, Saoulajan Guaouguaou, Fatima-Ezzahrae Omari, Nasreddine El Gallo, Monica Montesano, Domenico Zengin, Gokhan Taghzouti, Khalid Bouyahya, Abdelhakim |
author_sort | Aboulaghras, Sara |
collection | PubMed |
description | A flavone, chrysoeriol is synthetized in several plant species. It comes from several natural sources, especially medicinal plants. The identification and isolation of this compound has been carried out and verified by several research teams using different spectral methods. It seems that the concentration of this molecule is variable and fluctuating depending on the source, the part extracted, the region, and the methods of extraction and characterization. The aim of this paper is to highlight the in vitro and in vivo pharmacological properties of chrysoeriol and to provide insight into its pharmacokinetics. Anticancer, anti-inflammatory, antibacterial, antifungal, anti-osteoporosis, anti-insecticide, and neuroprotective actions have been shown in a number of studies on this chemical. Different mechanisms in theses pharmacological effects include subcellular, cellular, and molecular targets. In vivo pharmacokinetic analysis has proved the good stability of this molecule, showing its promising potential to prevent or treat diseases including cancer, diabetes, inflammation, osteoporosis, Parkinson’s disease, and cardiovascular diseases. |
format | Online Article Text |
id | pubmed-9415049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94150492022-08-27 Health Benefits and Pharmacological Aspects of Chrysoeriol Aboulaghras, Sara Sahib, Nargis Bakrim, Saad Benali, Taoufiq Charfi, Saoulajan Guaouguaou, Fatima-Ezzahrae Omari, Nasreddine El Gallo, Monica Montesano, Domenico Zengin, Gokhan Taghzouti, Khalid Bouyahya, Abdelhakim Pharmaceuticals (Basel) Review A flavone, chrysoeriol is synthetized in several plant species. It comes from several natural sources, especially medicinal plants. The identification and isolation of this compound has been carried out and verified by several research teams using different spectral methods. It seems that the concentration of this molecule is variable and fluctuating depending on the source, the part extracted, the region, and the methods of extraction and characterization. The aim of this paper is to highlight the in vitro and in vivo pharmacological properties of chrysoeriol and to provide insight into its pharmacokinetics. Anticancer, anti-inflammatory, antibacterial, antifungal, anti-osteoporosis, anti-insecticide, and neuroprotective actions have been shown in a number of studies on this chemical. Different mechanisms in theses pharmacological effects include subcellular, cellular, and molecular targets. In vivo pharmacokinetic analysis has proved the good stability of this molecule, showing its promising potential to prevent or treat diseases including cancer, diabetes, inflammation, osteoporosis, Parkinson’s disease, and cardiovascular diseases. MDPI 2022-08-07 /pmc/articles/PMC9415049/ /pubmed/36015121 http://dx.doi.org/10.3390/ph15080973 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aboulaghras, Sara Sahib, Nargis Bakrim, Saad Benali, Taoufiq Charfi, Saoulajan Guaouguaou, Fatima-Ezzahrae Omari, Nasreddine El Gallo, Monica Montesano, Domenico Zengin, Gokhan Taghzouti, Khalid Bouyahya, Abdelhakim Health Benefits and Pharmacological Aspects of Chrysoeriol |
title | Health Benefits and Pharmacological Aspects of Chrysoeriol |
title_full | Health Benefits and Pharmacological Aspects of Chrysoeriol |
title_fullStr | Health Benefits and Pharmacological Aspects of Chrysoeriol |
title_full_unstemmed | Health Benefits and Pharmacological Aspects of Chrysoeriol |
title_short | Health Benefits and Pharmacological Aspects of Chrysoeriol |
title_sort | health benefits and pharmacological aspects of chrysoeriol |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415049/ https://www.ncbi.nlm.nih.gov/pubmed/36015121 http://dx.doi.org/10.3390/ph15080973 |
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