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LC3-Associated Phagocytosis in Bacterial Infection

LC3-associated phagocytosis (LAP) is a noncanonical autophagy process reported in recent years and is one of the effective mechanisms of host defense against bacterial infection. During LAP, bacteria are recognized by pattern recognition receptors (PRRs), enter the body, and then recruit LC3 onto a...

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Detalles Bibliográficos
Autores principales: Yuan, Jin, Zhang, Qiuyu, Chen, Shihua, Yan, Min, Yue, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415076/
https://www.ncbi.nlm.nih.gov/pubmed/36014984
http://dx.doi.org/10.3390/pathogens11080863
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author Yuan, Jin
Zhang, Qiuyu
Chen, Shihua
Yan, Min
Yue, Lei
author_facet Yuan, Jin
Zhang, Qiuyu
Chen, Shihua
Yan, Min
Yue, Lei
author_sort Yuan, Jin
collection PubMed
description LC3-associated phagocytosis (LAP) is a noncanonical autophagy process reported in recent years and is one of the effective mechanisms of host defense against bacterial infection. During LAP, bacteria are recognized by pattern recognition receptors (PRRs), enter the body, and then recruit LC3 onto a single-membrane phagosome to form a LAPosome. LC3 conjugation can promote the fusion of the LAPosomes with lysosomes, resulting in their maturation into phagolysosomes, which can effectively kill the identified pathogens. However, to survive in host cells, bacteria have also evolved strategies to evade killing by LAP. In this review, we summarized the mechanism of LAP in resistance to bacterial infection and the ways in which bacteria escape LAP. We aim to provide new clues for developing novel therapeutic strategies for bacterial infectious diseases.
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spelling pubmed-94150762022-08-27 LC3-Associated Phagocytosis in Bacterial Infection Yuan, Jin Zhang, Qiuyu Chen, Shihua Yan, Min Yue, Lei Pathogens Review LC3-associated phagocytosis (LAP) is a noncanonical autophagy process reported in recent years and is one of the effective mechanisms of host defense against bacterial infection. During LAP, bacteria are recognized by pattern recognition receptors (PRRs), enter the body, and then recruit LC3 onto a single-membrane phagosome to form a LAPosome. LC3 conjugation can promote the fusion of the LAPosomes with lysosomes, resulting in their maturation into phagolysosomes, which can effectively kill the identified pathogens. However, to survive in host cells, bacteria have also evolved strategies to evade killing by LAP. In this review, we summarized the mechanism of LAP in resistance to bacterial infection and the ways in which bacteria escape LAP. We aim to provide new clues for developing novel therapeutic strategies for bacterial infectious diseases. MDPI 2022-07-30 /pmc/articles/PMC9415076/ /pubmed/36014984 http://dx.doi.org/10.3390/pathogens11080863 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yuan, Jin
Zhang, Qiuyu
Chen, Shihua
Yan, Min
Yue, Lei
LC3-Associated Phagocytosis in Bacterial Infection
title LC3-Associated Phagocytosis in Bacterial Infection
title_full LC3-Associated Phagocytosis in Bacterial Infection
title_fullStr LC3-Associated Phagocytosis in Bacterial Infection
title_full_unstemmed LC3-Associated Phagocytosis in Bacterial Infection
title_short LC3-Associated Phagocytosis in Bacterial Infection
title_sort lc3-associated phagocytosis in bacterial infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415076/
https://www.ncbi.nlm.nih.gov/pubmed/36014984
http://dx.doi.org/10.3390/pathogens11080863
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