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Accumulation of Sulforaphane and Alliin in Human Prostate Tissue
Diets rich in cruciferous vegetables have been associated with a lower risk of incidence and progression of prostate cancer. Sulforaphane, an isothiocyanate derived from 4-methylsulphinylbutyl glucosinolate (glucoraphanin) that accumulates in certain of these vegetables, notably broccoli, has been i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415180/ https://www.ncbi.nlm.nih.gov/pubmed/36014767 http://dx.doi.org/10.3390/nu14163263 |
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author | Livingstone, Tracey L. Saha, Shikha Bernuzzi, Federico Savva, George M. Troncoso-Rey, Perla Traka, Maria H. Mills, Robert D. Ball, Richard Y. Mithen, Richard F. |
author_facet | Livingstone, Tracey L. Saha, Shikha Bernuzzi, Federico Savva, George M. Troncoso-Rey, Perla Traka, Maria H. Mills, Robert D. Ball, Richard Y. Mithen, Richard F. |
author_sort | Livingstone, Tracey L. |
collection | PubMed |
description | Diets rich in cruciferous vegetables have been associated with a lower risk of incidence and progression of prostate cancer. Sulforaphane, an isothiocyanate derived from 4-methylsulphinylbutyl glucosinolate (glucoraphanin) that accumulates in certain of these vegetables, notably broccoli, has been implicated in their protective effects. Likewise, the consumption of garlic and its sulphur-containing compounds such as alliin have been associated with a reduction in risk of prostate cancer. In this study, we tested whether consuming glucoraphanin derived from broccoli seeds and alliin derived from garlic resulted in the occurrence of these potential bioactive compounds in the prostate, which may contribute to our understanding of the putative protective effects of these dietary components. We recruited 42 men scheduled for a trans-perineal prostate biopsy into a randomised, double-blinded, 2 × 2-factorial dietary supplement four-week intervention study, and 39 completed the study. The two active interventions were supplements providing glucoraphanin from broccoli (BroccoMax(®)) and alliin from garlic (Kwai Heartcare(®)). Following the intervention, prostate biopsy tissue was analysed for the presence of sulforaphane and its thiol conjugates and for alliin and associated metabolites. Sulforaphane occurred in significantly higher levels in the prostate tissue (both within the transition and peripheral zone) of men consuming the glucoraphanin containing supplements (p < 0.0001) compared to men not consuming these supplements. However, while alliin and alliin-derived metabolites were detected within the prostate, there was no significant difference in the concentrations of these compounds in the prostate of men consuming supplements derived from garlic compared to men not consuming these supplements. |
format | Online Article Text |
id | pubmed-9415180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94151802022-08-27 Accumulation of Sulforaphane and Alliin in Human Prostate Tissue Livingstone, Tracey L. Saha, Shikha Bernuzzi, Federico Savva, George M. Troncoso-Rey, Perla Traka, Maria H. Mills, Robert D. Ball, Richard Y. Mithen, Richard F. Nutrients Article Diets rich in cruciferous vegetables have been associated with a lower risk of incidence and progression of prostate cancer. Sulforaphane, an isothiocyanate derived from 4-methylsulphinylbutyl glucosinolate (glucoraphanin) that accumulates in certain of these vegetables, notably broccoli, has been implicated in their protective effects. Likewise, the consumption of garlic and its sulphur-containing compounds such as alliin have been associated with a reduction in risk of prostate cancer. In this study, we tested whether consuming glucoraphanin derived from broccoli seeds and alliin derived from garlic resulted in the occurrence of these potential bioactive compounds in the prostate, which may contribute to our understanding of the putative protective effects of these dietary components. We recruited 42 men scheduled for a trans-perineal prostate biopsy into a randomised, double-blinded, 2 × 2-factorial dietary supplement four-week intervention study, and 39 completed the study. The two active interventions were supplements providing glucoraphanin from broccoli (BroccoMax(®)) and alliin from garlic (Kwai Heartcare(®)). Following the intervention, prostate biopsy tissue was analysed for the presence of sulforaphane and its thiol conjugates and for alliin and associated metabolites. Sulforaphane occurred in significantly higher levels in the prostate tissue (both within the transition and peripheral zone) of men consuming the glucoraphanin containing supplements (p < 0.0001) compared to men not consuming these supplements. However, while alliin and alliin-derived metabolites were detected within the prostate, there was no significant difference in the concentrations of these compounds in the prostate of men consuming supplements derived from garlic compared to men not consuming these supplements. MDPI 2022-08-10 /pmc/articles/PMC9415180/ /pubmed/36014767 http://dx.doi.org/10.3390/nu14163263 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Livingstone, Tracey L. Saha, Shikha Bernuzzi, Federico Savva, George M. Troncoso-Rey, Perla Traka, Maria H. Mills, Robert D. Ball, Richard Y. Mithen, Richard F. Accumulation of Sulforaphane and Alliin in Human Prostate Tissue |
title | Accumulation of Sulforaphane and Alliin in Human Prostate Tissue |
title_full | Accumulation of Sulforaphane and Alliin in Human Prostate Tissue |
title_fullStr | Accumulation of Sulforaphane and Alliin in Human Prostate Tissue |
title_full_unstemmed | Accumulation of Sulforaphane and Alliin in Human Prostate Tissue |
title_short | Accumulation of Sulforaphane and Alliin in Human Prostate Tissue |
title_sort | accumulation of sulforaphane and alliin in human prostate tissue |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415180/ https://www.ncbi.nlm.nih.gov/pubmed/36014767 http://dx.doi.org/10.3390/nu14163263 |
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