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Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL

BACKGROUND: Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disease and treatment-related immune deficiency. The aim of this study was to assess...

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Autores principales: Antic, Darko, Milic, Natasa, Chatzikonstantinou, Thomas, Scarfò, Lydia, Otasevic, Vladimir, Rajovic, Nina, Allsup, David, Alonso Cabrero, Alejandro, Andres, Martin, Baile Gonzales, Monica, Capasso, Antonella, Collado, Rosa, Cordoba, Raul, Cuéllar-García, Carolina, Correa, Juan Gonzalo, De Paoli, Lorenzo, De Paolis, Maria Rosaria, Del Poeta, Giovanni, Dimou, Maria, Doubek, Michael, Efstathopoulou, Maria, El-Ashwah, Shaimaa, Enrico, Alicia, Espinet, Blanca, Farina, Lucia, Ferrari, Angela, Foglietta, Myriam, Lopez-Garcia, Alberto, García-Marco, José A., García-Serra, Rocío, Gentile, Massimo, Gimeno, Eva, da Silva, Maria Gomes, Gutwein, Odit, Hakobyan, Yervand K., Herishanu, Yair, Hernández-Rivas, José Ángel, Herold, Tobias, Itchaki, Gilad, Jaksic, Ozren, Janssens, Ann, Kalashnikova, Olga B., Kalicińska, Elżbieta, Kater, Arnon P., Kersting, Sabina, Koren-Michowitz, Maya, Labrador, Jorge, Lad, Deepesh, Laurenti, Luca, Fresa, Alberto, Levin, Mark-David, Mayor Bastida, Carlota, Malerba, Lara, Marasca, Roberto, Marchetti, Monia, Marquet, Juan, Mihaljevic, Biljana, Milosevic, Ivana, Mirás, Fatima, Morawska, Marta, Motta, Marina, Munir, Talha, Murru, Roberta, Nunes, Raquel, Olivieri, Jacopo, Pavlovsky, Miguel Arturo, Piskunova, Inga, Popov, Viola Maria, Quaglia, Francesca Maria, Quaresmini, Giulia, Reda, Gianluigi, Rigolin, Gian Matteo, Shrestha, Amit, Šimkovič, Martin, Smirnova, Svetlana, Špaček, Martin, Sportoletti, Paolo, Stanca, Oana, Stavroyianni, Niki, Te Raa, Doreen, Tomic, Kristina, Tonino, Sanne, Trentin, Livio, Van Der Spek, Ellen, van Gelder, Michel, Varettoni, Marzia, Visentin, Andrea, Vitale, Candida, Vukovic, Vojin, Wasik-Szczepanek, Ewa, Wróbel, Tomasz, Segundo, Lucrecia Yáñez San, Yassin, Mohamed, Coscia, Marta, Rambaldi, Alessandro, Montserrat, Emili, Foà, Robin, Cuneo, Antonio, Carrier, Marc, Ghia, Paolo, Stamatopoulos, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415249/
https://www.ncbi.nlm.nih.gov/pubmed/36028857
http://dx.doi.org/10.1186/s13045-022-01333-0
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author Antic, Darko
Milic, Natasa
Chatzikonstantinou, Thomas
Scarfò, Lydia
Otasevic, Vladimir
Rajovic, Nina
Allsup, David
Alonso Cabrero, Alejandro
Andres, Martin
Baile Gonzales, Monica
Capasso, Antonella
Collado, Rosa
Cordoba, Raul
Cuéllar-García, Carolina
Correa, Juan Gonzalo
De Paoli, Lorenzo
De Paolis, Maria Rosaria
Del Poeta, Giovanni
Dimou, Maria
Doubek, Michael
Efstathopoulou, Maria
El-Ashwah, Shaimaa
Enrico, Alicia
Espinet, Blanca
Farina, Lucia
Ferrari, Angela
Foglietta, Myriam
Lopez-Garcia, Alberto
García-Marco, José A.
García-Serra, Rocío
Gentile, Massimo
Gimeno, Eva
da Silva, Maria Gomes
Gutwein, Odit
Hakobyan, Yervand K.
Herishanu, Yair
Hernández-Rivas, José Ángel
Herold, Tobias
Itchaki, Gilad
Jaksic, Ozren
Janssens, Ann
Kalashnikova, Olga B.
Kalicińska, Elżbieta
Kater, Arnon P.
Kersting, Sabina
Koren-Michowitz, Maya
Labrador, Jorge
Lad, Deepesh
Laurenti, Luca
Fresa, Alberto
Levin, Mark-David
Mayor Bastida, Carlota
Malerba, Lara
Marasca, Roberto
Marchetti, Monia
Marquet, Juan
Mihaljevic, Biljana
Milosevic, Ivana
Mirás, Fatima
Morawska, Marta
Motta, Marina
Munir, Talha
Murru, Roberta
Nunes, Raquel
Olivieri, Jacopo
Pavlovsky, Miguel Arturo
Piskunova, Inga
Popov, Viola Maria
Quaglia, Francesca Maria
Quaresmini, Giulia
Reda, Gianluigi
Rigolin, Gian Matteo
Shrestha, Amit
Šimkovič, Martin
Smirnova, Svetlana
Špaček, Martin
Sportoletti, Paolo
Stanca, Oana
Stavroyianni, Niki
Te Raa, Doreen
Tomic, Kristina
Tonino, Sanne
Trentin, Livio
Van Der Spek, Ellen
van Gelder, Michel
Varettoni, Marzia
Visentin, Andrea
Vitale, Candida
Vukovic, Vojin
Wasik-Szczepanek, Ewa
Wróbel, Tomasz
Segundo, Lucrecia Yáñez San
Yassin, Mohamed
Coscia, Marta
Rambaldi, Alessandro
Montserrat, Emili
Foà, Robin
Cuneo, Antonio
Carrier, Marc
Ghia, Paolo
Stamatopoulos, Kostas
author_facet Antic, Darko
Milic, Natasa
Chatzikonstantinou, Thomas
Scarfò, Lydia
Otasevic, Vladimir
Rajovic, Nina
Allsup, David
Alonso Cabrero, Alejandro
Andres, Martin
Baile Gonzales, Monica
Capasso, Antonella
Collado, Rosa
Cordoba, Raul
Cuéllar-García, Carolina
Correa, Juan Gonzalo
De Paoli, Lorenzo
De Paolis, Maria Rosaria
Del Poeta, Giovanni
Dimou, Maria
Doubek, Michael
Efstathopoulou, Maria
El-Ashwah, Shaimaa
Enrico, Alicia
Espinet, Blanca
Farina, Lucia
Ferrari, Angela
Foglietta, Myriam
Lopez-Garcia, Alberto
García-Marco, José A.
García-Serra, Rocío
Gentile, Massimo
Gimeno, Eva
da Silva, Maria Gomes
Gutwein, Odit
Hakobyan, Yervand K.
Herishanu, Yair
Hernández-Rivas, José Ángel
Herold, Tobias
Itchaki, Gilad
Jaksic, Ozren
Janssens, Ann
Kalashnikova, Olga B.
Kalicińska, Elżbieta
Kater, Arnon P.
Kersting, Sabina
Koren-Michowitz, Maya
Labrador, Jorge
Lad, Deepesh
Laurenti, Luca
Fresa, Alberto
Levin, Mark-David
Mayor Bastida, Carlota
Malerba, Lara
Marasca, Roberto
Marchetti, Monia
Marquet, Juan
Mihaljevic, Biljana
Milosevic, Ivana
Mirás, Fatima
Morawska, Marta
Motta, Marina
Munir, Talha
Murru, Roberta
Nunes, Raquel
Olivieri, Jacopo
Pavlovsky, Miguel Arturo
Piskunova, Inga
Popov, Viola Maria
Quaglia, Francesca Maria
Quaresmini, Giulia
Reda, Gianluigi
Rigolin, Gian Matteo
Shrestha, Amit
Šimkovič, Martin
Smirnova, Svetlana
Špaček, Martin
Sportoletti, Paolo
Stanca, Oana
Stavroyianni, Niki
Te Raa, Doreen
Tomic, Kristina
Tonino, Sanne
Trentin, Livio
Van Der Spek, Ellen
van Gelder, Michel
Varettoni, Marzia
Visentin, Andrea
Vitale, Candida
Vukovic, Vojin
Wasik-Szczepanek, Ewa
Wróbel, Tomasz
Segundo, Lucrecia Yáñez San
Yassin, Mohamed
Coscia, Marta
Rambaldi, Alessandro
Montserrat, Emili
Foà, Robin
Cuneo, Antonio
Carrier, Marc
Ghia, Paolo
Stamatopoulos, Kostas
author_sort Antic, Darko
collection PubMed
description BACKGROUND: Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disease and treatment-related immune deficiency. The aim of this study was to assess the risk of thrombosis and bleeding in patients with CLL affected by severe COVID-19. METHODS: This is a retrospective multicenter study conducted by ERIC, the European Research Initiative on CLL, including patients from 79 centers across 22 countries. Data collection was conducted between April and May 2021. The COVID-19 diagnosis was confirmed by the real-time polymerase chain reaction (RT-PCR) assay for SARS-CoV-2 on nasal or pharyngeal swabs. Severe cases of COVID-19 were defined by hospitalization and the need of oxygen or admission into ICU. Development and type of thrombotic events, presence and severity of bleeding complications were reported during treatment for COVID-19. Bleeding events were classified using ISTH definition. STROBE recommendations were used in order to enhance reporting. RESULTS: A total of 793 patients from 79 centers were included in the study with 593 being hospitalized (74.8%). Among these, 511 were defined as having severe COVID: 162 were admitted to the ICU while 349 received oxygen supplementation outside the ICU. Most patients (90.5%) were receiving thromboprophylaxis. During COVID-19 treatment, 11.1% developed a thromboembolic event, while 5.0% experienced bleeding. Thrombosis developed in 21.6% of patients who were not receiving thromboprophylaxis, in contrast to 10.6% of patients who were on thromboprophylaxis. Bleeding episodes were more frequent in patients receiving intermediate/therapeutic versus prophylactic doses of low-molecular-weight heparin (LWMH) (8.1% vs. 3.8%, respectively) and in elderly. In multivariate analysis, peak D-dimer level and C-reactive protein to albumin ratio were poor prognostic factors for thrombosis occurrence (OR = 1.022, 95%CI 1.007‒1.038 and OR = 1.025, 95%CI 1.001‒1.051, respectively), while thromboprophylaxis use was protective (OR = 0.199, 95%CI 0.061‒0.645). Age and LMWH intermediate/therapeutic dose administration were prognostic factors in multivariate model for bleeding (OR = 1.062, 95%CI 1.017–1.109 and OR = 2.438, 95%CI 1.023–5.813, respectively). CONCLUSIONS: Patients with CLL affected by severe COVID-19 are at a high risk of thrombosis if thromboprophylaxis is not used, but also at increased risk of bleeding under the LMWH intermediate/therapeutic dose administration.
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spelling pubmed-94152492022-08-26 Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL Antic, Darko Milic, Natasa Chatzikonstantinou, Thomas Scarfò, Lydia Otasevic, Vladimir Rajovic, Nina Allsup, David Alonso Cabrero, Alejandro Andres, Martin Baile Gonzales, Monica Capasso, Antonella Collado, Rosa Cordoba, Raul Cuéllar-García, Carolina Correa, Juan Gonzalo De Paoli, Lorenzo De Paolis, Maria Rosaria Del Poeta, Giovanni Dimou, Maria Doubek, Michael Efstathopoulou, Maria El-Ashwah, Shaimaa Enrico, Alicia Espinet, Blanca Farina, Lucia Ferrari, Angela Foglietta, Myriam Lopez-Garcia, Alberto García-Marco, José A. García-Serra, Rocío Gentile, Massimo Gimeno, Eva da Silva, Maria Gomes Gutwein, Odit Hakobyan, Yervand K. Herishanu, Yair Hernández-Rivas, José Ángel Herold, Tobias Itchaki, Gilad Jaksic, Ozren Janssens, Ann Kalashnikova, Olga B. Kalicińska, Elżbieta Kater, Arnon P. Kersting, Sabina Koren-Michowitz, Maya Labrador, Jorge Lad, Deepesh Laurenti, Luca Fresa, Alberto Levin, Mark-David Mayor Bastida, Carlota Malerba, Lara Marasca, Roberto Marchetti, Monia Marquet, Juan Mihaljevic, Biljana Milosevic, Ivana Mirás, Fatima Morawska, Marta Motta, Marina Munir, Talha Murru, Roberta Nunes, Raquel Olivieri, Jacopo Pavlovsky, Miguel Arturo Piskunova, Inga Popov, Viola Maria Quaglia, Francesca Maria Quaresmini, Giulia Reda, Gianluigi Rigolin, Gian Matteo Shrestha, Amit Šimkovič, Martin Smirnova, Svetlana Špaček, Martin Sportoletti, Paolo Stanca, Oana Stavroyianni, Niki Te Raa, Doreen Tomic, Kristina Tonino, Sanne Trentin, Livio Van Der Spek, Ellen van Gelder, Michel Varettoni, Marzia Visentin, Andrea Vitale, Candida Vukovic, Vojin Wasik-Szczepanek, Ewa Wróbel, Tomasz Segundo, Lucrecia Yáñez San Yassin, Mohamed Coscia, Marta Rambaldi, Alessandro Montserrat, Emili Foà, Robin Cuneo, Antonio Carrier, Marc Ghia, Paolo Stamatopoulos, Kostas J Hematol Oncol Research BACKGROUND: Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disease and treatment-related immune deficiency. The aim of this study was to assess the risk of thrombosis and bleeding in patients with CLL affected by severe COVID-19. METHODS: This is a retrospective multicenter study conducted by ERIC, the European Research Initiative on CLL, including patients from 79 centers across 22 countries. Data collection was conducted between April and May 2021. The COVID-19 diagnosis was confirmed by the real-time polymerase chain reaction (RT-PCR) assay for SARS-CoV-2 on nasal or pharyngeal swabs. Severe cases of COVID-19 were defined by hospitalization and the need of oxygen or admission into ICU. Development and type of thrombotic events, presence and severity of bleeding complications were reported during treatment for COVID-19. Bleeding events were classified using ISTH definition. STROBE recommendations were used in order to enhance reporting. RESULTS: A total of 793 patients from 79 centers were included in the study with 593 being hospitalized (74.8%). Among these, 511 were defined as having severe COVID: 162 were admitted to the ICU while 349 received oxygen supplementation outside the ICU. Most patients (90.5%) were receiving thromboprophylaxis. During COVID-19 treatment, 11.1% developed a thromboembolic event, while 5.0% experienced bleeding. Thrombosis developed in 21.6% of patients who were not receiving thromboprophylaxis, in contrast to 10.6% of patients who were on thromboprophylaxis. Bleeding episodes were more frequent in patients receiving intermediate/therapeutic versus prophylactic doses of low-molecular-weight heparin (LWMH) (8.1% vs. 3.8%, respectively) and in elderly. In multivariate analysis, peak D-dimer level and C-reactive protein to albumin ratio were poor prognostic factors for thrombosis occurrence (OR = 1.022, 95%CI 1.007‒1.038 and OR = 1.025, 95%CI 1.001‒1.051, respectively), while thromboprophylaxis use was protective (OR = 0.199, 95%CI 0.061‒0.645). Age and LMWH intermediate/therapeutic dose administration were prognostic factors in multivariate model for bleeding (OR = 1.062, 95%CI 1.017–1.109 and OR = 2.438, 95%CI 1.023–5.813, respectively). CONCLUSIONS: Patients with CLL affected by severe COVID-19 are at a high risk of thrombosis if thromboprophylaxis is not used, but also at increased risk of bleeding under the LMWH intermediate/therapeutic dose administration. BioMed Central 2022-08-26 /pmc/articles/PMC9415249/ /pubmed/36028857 http://dx.doi.org/10.1186/s13045-022-01333-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Antic, Darko
Milic, Natasa
Chatzikonstantinou, Thomas
Scarfò, Lydia
Otasevic, Vladimir
Rajovic, Nina
Allsup, David
Alonso Cabrero, Alejandro
Andres, Martin
Baile Gonzales, Monica
Capasso, Antonella
Collado, Rosa
Cordoba, Raul
Cuéllar-García, Carolina
Correa, Juan Gonzalo
De Paoli, Lorenzo
De Paolis, Maria Rosaria
Del Poeta, Giovanni
Dimou, Maria
Doubek, Michael
Efstathopoulou, Maria
El-Ashwah, Shaimaa
Enrico, Alicia
Espinet, Blanca
Farina, Lucia
Ferrari, Angela
Foglietta, Myriam
Lopez-Garcia, Alberto
García-Marco, José A.
García-Serra, Rocío
Gentile, Massimo
Gimeno, Eva
da Silva, Maria Gomes
Gutwein, Odit
Hakobyan, Yervand K.
Herishanu, Yair
Hernández-Rivas, José Ángel
Herold, Tobias
Itchaki, Gilad
Jaksic, Ozren
Janssens, Ann
Kalashnikova, Olga B.
Kalicińska, Elżbieta
Kater, Arnon P.
Kersting, Sabina
Koren-Michowitz, Maya
Labrador, Jorge
Lad, Deepesh
Laurenti, Luca
Fresa, Alberto
Levin, Mark-David
Mayor Bastida, Carlota
Malerba, Lara
Marasca, Roberto
Marchetti, Monia
Marquet, Juan
Mihaljevic, Biljana
Milosevic, Ivana
Mirás, Fatima
Morawska, Marta
Motta, Marina
Munir, Talha
Murru, Roberta
Nunes, Raquel
Olivieri, Jacopo
Pavlovsky, Miguel Arturo
Piskunova, Inga
Popov, Viola Maria
Quaglia, Francesca Maria
Quaresmini, Giulia
Reda, Gianluigi
Rigolin, Gian Matteo
Shrestha, Amit
Šimkovič, Martin
Smirnova, Svetlana
Špaček, Martin
Sportoletti, Paolo
Stanca, Oana
Stavroyianni, Niki
Te Raa, Doreen
Tomic, Kristina
Tonino, Sanne
Trentin, Livio
Van Der Spek, Ellen
van Gelder, Michel
Varettoni, Marzia
Visentin, Andrea
Vitale, Candida
Vukovic, Vojin
Wasik-Szczepanek, Ewa
Wróbel, Tomasz
Segundo, Lucrecia Yáñez San
Yassin, Mohamed
Coscia, Marta
Rambaldi, Alessandro
Montserrat, Emili
Foà, Robin
Cuneo, Antonio
Carrier, Marc
Ghia, Paolo
Stamatopoulos, Kostas
Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
title Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
title_full Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
title_fullStr Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
title_full_unstemmed Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
title_short Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
title_sort thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe covid-19: a study of eric, the european research initiative on cll
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415249/
https://www.ncbi.nlm.nih.gov/pubmed/36028857
http://dx.doi.org/10.1186/s13045-022-01333-0
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AT kalicinskaelzbieta thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT katerarnonp thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT kerstingsabina thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT korenmichowitzmaya thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT labradorjorge thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT laddeepesh thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT laurentiluca thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT fresaalberto thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT levinmarkdavid thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT mayorbastidacarlota thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT malerbalara thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT marascaroberto thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT marchettimonia thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT marquetjuan thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT mihaljevicbiljana thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT milosevicivana thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT mirasfatima thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT morawskamarta thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT mottamarina thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT munirtalha thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT murruroberta thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT nunesraquel thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT olivierijacopo thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT pavlovskymiguelarturo thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT piskunovainga thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT popovviolamaria thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT quagliafrancescamaria thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT quaresminigiulia thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT redagianluigi thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT rigolingianmatteo thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT shresthaamit thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT simkovicmartin thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT smirnovasvetlana thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT spacekmartin thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT sportolettipaolo thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT stancaoana thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT stavroyianniniki thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT teraadoreen thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT tomickristina thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT toninosanne thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT trentinlivio thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT vanderspekellen thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT vangeldermichel thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT varettonimarzia thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT visentinandrea thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT vitalecandida thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT vukovicvojin thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT wasikszczepanekewa thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT wrobeltomasz thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT segundolucreciayanezsan thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT yassinmohamed thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT cosciamarta thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT rambaldialessandro thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT montserratemili thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT foarobin thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT cuneoantonio thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT carriermarc thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT ghiapaolo thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll
AT stamatopouloskostas thromboticandbleedingcomplicationsinpatientswithchroniclymphocyticleukemiaandseverecovid19astudyoferictheeuropeanresearchinitiativeoncll