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Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study

Vitamin D is essential for calcium absorption and bone homeostasis. Although short-stature children were reported to have low vitamin D concentrations, there is no clear evidence of a link between vitamin D and height growth in young children not limited to those with short stature. We collected hei...

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Autores principales: Kuraoka, Shohei, Oda, Masako, Mitsubuchi, Hiroshi, Nakamura, Kimitoshi, Katoh, Takahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415323/
https://www.ncbi.nlm.nih.gov/pubmed/36014831
http://dx.doi.org/10.3390/nu14163325
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author Kuraoka, Shohei
Oda, Masako
Mitsubuchi, Hiroshi
Nakamura, Kimitoshi
Katoh, Takahiko
author_facet Kuraoka, Shohei
Oda, Masako
Mitsubuchi, Hiroshi
Nakamura, Kimitoshi
Katoh, Takahiko
author_sort Kuraoka, Shohei
collection PubMed
description Vitamin D is essential for calcium absorption and bone homeostasis. Although short-stature children were reported to have low vitamin D concentrations, there is no clear evidence of a link between vitamin D and height growth in young children not limited to those with short stature. We collected height and weight data at 2 and 4 years of age, serum vitamin D concentrations at 4 years, and questionnaire results on sun exposure from the Japan Environment and Children’s Study (JECS). We then analyzed the relationship between vitamin D deficiency and height growth. We also analyzed the correlation between serum vitamin D concentration and sun exposure. Overall, 3624 participants from JECS were analyzed. We identified cases of subclinical vitamin D deficiency and insufficiency. We further found that definitive vitamin D deficiency (<10 ng/mL) impaired height growth by 0.6 cm per year even in young children not limited to those with short stature. Furthermore, we clarified that children with vitamin D deficiency had reduced outdoor activity, especially during winter. In children with either short or normal stature, definitive vitamin D deficiency was associated with height growth decline, and reduction in outdoor activity, especially during winter, was a risk factor for vitamin D deficiency.
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spelling pubmed-94153232022-08-27 Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study Kuraoka, Shohei Oda, Masako Mitsubuchi, Hiroshi Nakamura, Kimitoshi Katoh, Takahiko Nutrients Article Vitamin D is essential for calcium absorption and bone homeostasis. Although short-stature children were reported to have low vitamin D concentrations, there is no clear evidence of a link between vitamin D and height growth in young children not limited to those with short stature. We collected height and weight data at 2 and 4 years of age, serum vitamin D concentrations at 4 years, and questionnaire results on sun exposure from the Japan Environment and Children’s Study (JECS). We then analyzed the relationship between vitamin D deficiency and height growth. We also analyzed the correlation between serum vitamin D concentration and sun exposure. Overall, 3624 participants from JECS were analyzed. We identified cases of subclinical vitamin D deficiency and insufficiency. We further found that definitive vitamin D deficiency (<10 ng/mL) impaired height growth by 0.6 cm per year even in young children not limited to those with short stature. Furthermore, we clarified that children with vitamin D deficiency had reduced outdoor activity, especially during winter. In children with either short or normal stature, definitive vitamin D deficiency was associated with height growth decline, and reduction in outdoor activity, especially during winter, was a risk factor for vitamin D deficiency. MDPI 2022-08-13 /pmc/articles/PMC9415323/ /pubmed/36014831 http://dx.doi.org/10.3390/nu14163325 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuraoka, Shohei
Oda, Masako
Mitsubuchi, Hiroshi
Nakamura, Kimitoshi
Katoh, Takahiko
Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study
title Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study
title_full Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study
title_fullStr Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study
title_full_unstemmed Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study
title_short Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study
title_sort impaired height growth associated with vitamin d deficiency in young children from the japan environment and children’s study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415323/
https://www.ncbi.nlm.nih.gov/pubmed/36014831
http://dx.doi.org/10.3390/nu14163325
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