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Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study
Vitamin D is essential for calcium absorption and bone homeostasis. Although short-stature children were reported to have low vitamin D concentrations, there is no clear evidence of a link between vitamin D and height growth in young children not limited to those with short stature. We collected hei...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415323/ https://www.ncbi.nlm.nih.gov/pubmed/36014831 http://dx.doi.org/10.3390/nu14163325 |
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author | Kuraoka, Shohei Oda, Masako Mitsubuchi, Hiroshi Nakamura, Kimitoshi Katoh, Takahiko |
author_facet | Kuraoka, Shohei Oda, Masako Mitsubuchi, Hiroshi Nakamura, Kimitoshi Katoh, Takahiko |
author_sort | Kuraoka, Shohei |
collection | PubMed |
description | Vitamin D is essential for calcium absorption and bone homeostasis. Although short-stature children were reported to have low vitamin D concentrations, there is no clear evidence of a link between vitamin D and height growth in young children not limited to those with short stature. We collected height and weight data at 2 and 4 years of age, serum vitamin D concentrations at 4 years, and questionnaire results on sun exposure from the Japan Environment and Children’s Study (JECS). We then analyzed the relationship between vitamin D deficiency and height growth. We also analyzed the correlation between serum vitamin D concentration and sun exposure. Overall, 3624 participants from JECS were analyzed. We identified cases of subclinical vitamin D deficiency and insufficiency. We further found that definitive vitamin D deficiency (<10 ng/mL) impaired height growth by 0.6 cm per year even in young children not limited to those with short stature. Furthermore, we clarified that children with vitamin D deficiency had reduced outdoor activity, especially during winter. In children with either short or normal stature, definitive vitamin D deficiency was associated with height growth decline, and reduction in outdoor activity, especially during winter, was a risk factor for vitamin D deficiency. |
format | Online Article Text |
id | pubmed-9415323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94153232022-08-27 Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study Kuraoka, Shohei Oda, Masako Mitsubuchi, Hiroshi Nakamura, Kimitoshi Katoh, Takahiko Nutrients Article Vitamin D is essential for calcium absorption and bone homeostasis. Although short-stature children were reported to have low vitamin D concentrations, there is no clear evidence of a link between vitamin D and height growth in young children not limited to those with short stature. We collected height and weight data at 2 and 4 years of age, serum vitamin D concentrations at 4 years, and questionnaire results on sun exposure from the Japan Environment and Children’s Study (JECS). We then analyzed the relationship between vitamin D deficiency and height growth. We also analyzed the correlation between serum vitamin D concentration and sun exposure. Overall, 3624 participants from JECS were analyzed. We identified cases of subclinical vitamin D deficiency and insufficiency. We further found that definitive vitamin D deficiency (<10 ng/mL) impaired height growth by 0.6 cm per year even in young children not limited to those with short stature. Furthermore, we clarified that children with vitamin D deficiency had reduced outdoor activity, especially during winter. In children with either short or normal stature, definitive vitamin D deficiency was associated with height growth decline, and reduction in outdoor activity, especially during winter, was a risk factor for vitamin D deficiency. MDPI 2022-08-13 /pmc/articles/PMC9415323/ /pubmed/36014831 http://dx.doi.org/10.3390/nu14163325 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kuraoka, Shohei Oda, Masako Mitsubuchi, Hiroshi Nakamura, Kimitoshi Katoh, Takahiko Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study |
title | Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study |
title_full | Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study |
title_fullStr | Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study |
title_full_unstemmed | Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study |
title_short | Impaired Height Growth Associated with Vitamin D Deficiency in Young Children from the Japan Environment and Children’s Study |
title_sort | impaired height growth associated with vitamin d deficiency in young children from the japan environment and children’s study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415323/ https://www.ncbi.nlm.nih.gov/pubmed/36014831 http://dx.doi.org/10.3390/nu14163325 |
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