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Application of mRNA Technology in Cancer Therapeutics

mRNA-based therapeutics pose as promising treatment strategies for cancer immunotherapy. Improvements in materials and technology of delivery systems have helped to overcome major obstacles in generating a sufficient immune response required to fight a specific type of cancer. Several in vivo models...

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Detalles Bibliográficos
Autor principal: Eralp, Yesim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415393/
https://www.ncbi.nlm.nih.gov/pubmed/36016150
http://dx.doi.org/10.3390/vaccines10081262
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author Eralp, Yesim
author_facet Eralp, Yesim
author_sort Eralp, Yesim
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description mRNA-based therapeutics pose as promising treatment strategies for cancer immunotherapy. Improvements in materials and technology of delivery systems have helped to overcome major obstacles in generating a sufficient immune response required to fight a specific type of cancer. Several in vivo models and early clinical studies have suggested that various mRNA treatment platforms can induce cancer-specific cytolytic activity, leading to numerous clinical trials to determine the optimal method of combinations and sequencing with already established agents in cancer treatment. Nevertheless, further research is required to optimize RNA stabilization, delivery platforms, and improve clinical efficacy by interacting with the tumor microenvironment to induce a long-term antitumor response. This review provides a comprehensive summary of the available evidence on the recent advances and efforts to overcome existing challenges of mRNA-based treatment strategies, and how these efforts play key roles in offering perceptive insights into future considerations for clinical application.
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spelling pubmed-94153932022-08-27 Application of mRNA Technology in Cancer Therapeutics Eralp, Yesim Vaccines (Basel) Review mRNA-based therapeutics pose as promising treatment strategies for cancer immunotherapy. Improvements in materials and technology of delivery systems have helped to overcome major obstacles in generating a sufficient immune response required to fight a specific type of cancer. Several in vivo models and early clinical studies have suggested that various mRNA treatment platforms can induce cancer-specific cytolytic activity, leading to numerous clinical trials to determine the optimal method of combinations and sequencing with already established agents in cancer treatment. Nevertheless, further research is required to optimize RNA stabilization, delivery platforms, and improve clinical efficacy by interacting with the tumor microenvironment to induce a long-term antitumor response. This review provides a comprehensive summary of the available evidence on the recent advances and efforts to overcome existing challenges of mRNA-based treatment strategies, and how these efforts play key roles in offering perceptive insights into future considerations for clinical application. MDPI 2022-08-05 /pmc/articles/PMC9415393/ /pubmed/36016150 http://dx.doi.org/10.3390/vaccines10081262 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Eralp, Yesim
Application of mRNA Technology in Cancer Therapeutics
title Application of mRNA Technology in Cancer Therapeutics
title_full Application of mRNA Technology in Cancer Therapeutics
title_fullStr Application of mRNA Technology in Cancer Therapeutics
title_full_unstemmed Application of mRNA Technology in Cancer Therapeutics
title_short Application of mRNA Technology in Cancer Therapeutics
title_sort application of mrna technology in cancer therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415393/
https://www.ncbi.nlm.nih.gov/pubmed/36016150
http://dx.doi.org/10.3390/vaccines10081262
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