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Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina

Background and Objectives: The COVID-19 pandemic has led to significant changes globally, which has also affected patients with type 1 diabetes mellitus (T1DM). This study aimed to determine the incidence of T1DM and the characteristics of diabetic ketoacidosis (DKA) during the pandemic comparing it...

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Autores principales: Vorgučin, Ivana, Savin, Marijana, Stanković, Đurđina, Miljković, Dejan, Ilić, Tatjana, Simić, Danijela, Vrebalov, Mirjana, Milanović, Borko, Barišić, Nenad, Stojanović, Vesna, Vijatov-Đurić, Gordana, Koprivšek, Katarina, Vilotijević-Dautović, Gordana, Antić, Jelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415410/
https://www.ncbi.nlm.nih.gov/pubmed/36013479
http://dx.doi.org/10.3390/medicina58081013
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author Vorgučin, Ivana
Savin, Marijana
Stanković, Đurđina
Miljković, Dejan
Ilić, Tatjana
Simić, Danijela
Vrebalov, Mirjana
Milanović, Borko
Barišić, Nenad
Stojanović, Vesna
Vijatov-Đurić, Gordana
Koprivšek, Katarina
Vilotijević-Dautović, Gordana
Antić, Jelena
author_facet Vorgučin, Ivana
Savin, Marijana
Stanković, Đurđina
Miljković, Dejan
Ilić, Tatjana
Simić, Danijela
Vrebalov, Mirjana
Milanović, Borko
Barišić, Nenad
Stojanović, Vesna
Vijatov-Đurić, Gordana
Koprivšek, Katarina
Vilotijević-Dautović, Gordana
Antić, Jelena
author_sort Vorgučin, Ivana
collection PubMed
description Background and Objectives: The COVID-19 pandemic has led to significant changes globally, which has also affected patients with type 1 diabetes mellitus (T1DM). This study aimed to determine the incidence of T1DM and the characteristics of diabetic ketoacidosis (DKA) during the pandemic comparing it to pre-pandemic period. Materials and Methods: Data from patients <19 years with newly diagnosed T1DM between 1st January 2017 and 31st December 2021 from four regional centers in Vojvodina were retrospectively collected and analyzed. Results: In 2021, the highest incidence of T1DM in the last five years was recorded, 17.3/100,000. During the pandemic period (2020–2021), there were 99 new-onset T1DM, of which 42.4% presented in DKA, which is significantly higher than in the pre-pandemic period (34.1%). During the pandemic, symptom duration of T1DM lasted significantly longer than before the COVID-19 period. At the age of 10–14 years, the highest incidence of T1DM and COVID-19, the highest frequency rate of DKA, and severe DKA were observed. Conclusions: The pandemic is associated with a high incidence rate of T1DM, longer duration of symptoms of T1DM, a high frequency of DKA, and a severe DKA at diagnosis. Patients aged 10–14 years are a risk group for the occurrence of T1DM with severe clinical presentation. Additional studies are needed with a longer study period and in a wider geographical area, with data on exposure to COVID-19 infection, the permanence of new-onset T1DM, and the psychosocial impact of the pandemic.
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spelling pubmed-94154102022-08-27 Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina Vorgučin, Ivana Savin, Marijana Stanković, Đurđina Miljković, Dejan Ilić, Tatjana Simić, Danijela Vrebalov, Mirjana Milanović, Borko Barišić, Nenad Stojanović, Vesna Vijatov-Đurić, Gordana Koprivšek, Katarina Vilotijević-Dautović, Gordana Antić, Jelena Medicina (Kaunas) Article Background and Objectives: The COVID-19 pandemic has led to significant changes globally, which has also affected patients with type 1 diabetes mellitus (T1DM). This study aimed to determine the incidence of T1DM and the characteristics of diabetic ketoacidosis (DKA) during the pandemic comparing it to pre-pandemic period. Materials and Methods: Data from patients <19 years with newly diagnosed T1DM between 1st January 2017 and 31st December 2021 from four regional centers in Vojvodina were retrospectively collected and analyzed. Results: In 2021, the highest incidence of T1DM in the last five years was recorded, 17.3/100,000. During the pandemic period (2020–2021), there were 99 new-onset T1DM, of which 42.4% presented in DKA, which is significantly higher than in the pre-pandemic period (34.1%). During the pandemic, symptom duration of T1DM lasted significantly longer than before the COVID-19 period. At the age of 10–14 years, the highest incidence of T1DM and COVID-19, the highest frequency rate of DKA, and severe DKA were observed. Conclusions: The pandemic is associated with a high incidence rate of T1DM, longer duration of symptoms of T1DM, a high frequency of DKA, and a severe DKA at diagnosis. Patients aged 10–14 years are a risk group for the occurrence of T1DM with severe clinical presentation. Additional studies are needed with a longer study period and in a wider geographical area, with data on exposure to COVID-19 infection, the permanence of new-onset T1DM, and the psychosocial impact of the pandemic. MDPI 2022-07-28 /pmc/articles/PMC9415410/ /pubmed/36013479 http://dx.doi.org/10.3390/medicina58081013 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vorgučin, Ivana
Savin, Marijana
Stanković, Đurđina
Miljković, Dejan
Ilić, Tatjana
Simić, Danijela
Vrebalov, Mirjana
Milanović, Borko
Barišić, Nenad
Stojanović, Vesna
Vijatov-Đurić, Gordana
Koprivšek, Katarina
Vilotijević-Dautović, Gordana
Antić, Jelena
Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina
title Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina
title_full Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina
title_fullStr Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina
title_full_unstemmed Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina
title_short Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina
title_sort incidence of type 1 diabetes mellitus and characteristics of diabetic ketoacidosis in children and adolescents during the first two years of the covid-19 pandemic in vojvodina
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415410/
https://www.ncbi.nlm.nih.gov/pubmed/36013479
http://dx.doi.org/10.3390/medicina58081013
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