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Pericardial Involvement in Severe COVID-19 Patients

Background and Objectives: SARS-CoV-2 has an extensive tissue tropism due to its ability to attach to the surfaces of cells through different receptors, leading to systemic complications. In this article, we aim to present the prevalence of pericardial effusions in patients with severe COVID-19, to...

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Autores principales: Lazar, Mihai, Barbu, Ecaterina Constanta, Chitu, Cristina Emilia, Anghel, Ana-Maria-Jennifer, Niculae, Cristian-Mihail, Manea, Eliza-Daniela, Damalan, Anca-Cristina, Bel, Adela-Abigaela, Patrascu, Raluca-Elena, Hristea, Adriana, Ion, Daniela Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415465/
https://www.ncbi.nlm.nih.gov/pubmed/36013560
http://dx.doi.org/10.3390/medicina58081093
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author Lazar, Mihai
Barbu, Ecaterina Constanta
Chitu, Cristina Emilia
Anghel, Ana-Maria-Jennifer
Niculae, Cristian-Mihail
Manea, Eliza-Daniela
Damalan, Anca-Cristina
Bel, Adela-Abigaela
Patrascu, Raluca-Elena
Hristea, Adriana
Ion, Daniela Adriana
author_facet Lazar, Mihai
Barbu, Ecaterina Constanta
Chitu, Cristina Emilia
Anghel, Ana-Maria-Jennifer
Niculae, Cristian-Mihail
Manea, Eliza-Daniela
Damalan, Anca-Cristina
Bel, Adela-Abigaela
Patrascu, Raluca-Elena
Hristea, Adriana
Ion, Daniela Adriana
author_sort Lazar, Mihai
collection PubMed
description Background and Objectives: SARS-CoV-2 has an extensive tissue tropism due to its ability to attach to the surfaces of cells through different receptors, leading to systemic complications. In this article, we aim to present the prevalence of pericardial effusions in patients with severe COVID-19, to identify the risk factors/predictors for pericardial involvement, and to evaluate its impact on overall mortality. Materials and Methods: We enrolled 100 patients with severe COVID-19 in our observational cohort study and divided them in two groups: Group A (27 patients with pericardial effusion) and Group B (73 patients without pericardial effusion). We recorded demographic and lifestyle parameters, anthropometric parameters, clinical parameters, inflammation markers, respiratory function parameters, complete blood count, coagulation parameters, and biochemical serum parameters. All patients were evaluated by computer tomography scans within 48 h of admission. Results: The median age was 61 years in both groups and the male/female ratio was 3.5 vs. 2.8 in Group A vs. Group B. We identified mild pericardial effusion (3–4 mm) in 62.9% patients and moderate pericardial effusion (5–9 mm) in 37.1% patients, with a median value of 4 [3;6] mm. The patients with pericardial effusion presented with higher percentages of obesity, type-2 diabetes mellitus, arterial hypertension, and congestive heart failure, without statistical significance. Increased values in cardiac enzymes (myoglobin, CK, CK-MB) and LDH were statistically associated with pericardial effusion. The overall mortality among the participants of the study was 24% (24 patients), 33.3% in Group A and 20.8% in Group B. Conclusions: Pericardial effusion has a high prevalence (27%) among patients with severe forms of COVID-19 and was associated with higher mortality. Pericardial effusion in our study was not associated with the presence of comorbidities or the extent of lung involvement. Overall mortality was 60% higher in patients with pericardial effusion.
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spelling pubmed-94154652022-08-27 Pericardial Involvement in Severe COVID-19 Patients Lazar, Mihai Barbu, Ecaterina Constanta Chitu, Cristina Emilia Anghel, Ana-Maria-Jennifer Niculae, Cristian-Mihail Manea, Eliza-Daniela Damalan, Anca-Cristina Bel, Adela-Abigaela Patrascu, Raluca-Elena Hristea, Adriana Ion, Daniela Adriana Medicina (Kaunas) Article Background and Objectives: SARS-CoV-2 has an extensive tissue tropism due to its ability to attach to the surfaces of cells through different receptors, leading to systemic complications. In this article, we aim to present the prevalence of pericardial effusions in patients with severe COVID-19, to identify the risk factors/predictors for pericardial involvement, and to evaluate its impact on overall mortality. Materials and Methods: We enrolled 100 patients with severe COVID-19 in our observational cohort study and divided them in two groups: Group A (27 patients with pericardial effusion) and Group B (73 patients without pericardial effusion). We recorded demographic and lifestyle parameters, anthropometric parameters, clinical parameters, inflammation markers, respiratory function parameters, complete blood count, coagulation parameters, and biochemical serum parameters. All patients were evaluated by computer tomography scans within 48 h of admission. Results: The median age was 61 years in both groups and the male/female ratio was 3.5 vs. 2.8 in Group A vs. Group B. We identified mild pericardial effusion (3–4 mm) in 62.9% patients and moderate pericardial effusion (5–9 mm) in 37.1% patients, with a median value of 4 [3;6] mm. The patients with pericardial effusion presented with higher percentages of obesity, type-2 diabetes mellitus, arterial hypertension, and congestive heart failure, without statistical significance. Increased values in cardiac enzymes (myoglobin, CK, CK-MB) and LDH were statistically associated with pericardial effusion. The overall mortality among the participants of the study was 24% (24 patients), 33.3% in Group A and 20.8% in Group B. Conclusions: Pericardial effusion has a high prevalence (27%) among patients with severe forms of COVID-19 and was associated with higher mortality. Pericardial effusion in our study was not associated with the presence of comorbidities or the extent of lung involvement. Overall mortality was 60% higher in patients with pericardial effusion. MDPI 2022-08-12 /pmc/articles/PMC9415465/ /pubmed/36013560 http://dx.doi.org/10.3390/medicina58081093 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lazar, Mihai
Barbu, Ecaterina Constanta
Chitu, Cristina Emilia
Anghel, Ana-Maria-Jennifer
Niculae, Cristian-Mihail
Manea, Eliza-Daniela
Damalan, Anca-Cristina
Bel, Adela-Abigaela
Patrascu, Raluca-Elena
Hristea, Adriana
Ion, Daniela Adriana
Pericardial Involvement in Severe COVID-19 Patients
title Pericardial Involvement in Severe COVID-19 Patients
title_full Pericardial Involvement in Severe COVID-19 Patients
title_fullStr Pericardial Involvement in Severe COVID-19 Patients
title_full_unstemmed Pericardial Involvement in Severe COVID-19 Patients
title_short Pericardial Involvement in Severe COVID-19 Patients
title_sort pericardial involvement in severe covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415465/
https://www.ncbi.nlm.nih.gov/pubmed/36013560
http://dx.doi.org/10.3390/medicina58081093
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