The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients

Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer but there are very limited published data conc...

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Autores principales: Kottaridi, Christine, Resta, Panagiota, Leventakou, Danai, Gioti, Katerina, Zygouras, Ioannis, Gouloumi, Alina-Roxani, Sakagiannis, Georgios, Alzahrani, Khalid J., Venetikou, Maria S., Anthouli-Anagnostopoulou, Fragkiski, Beloukas, Apostolos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415711/
https://www.ncbi.nlm.nih.gov/pubmed/36016346
http://dx.doi.org/10.3390/v14081724
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author Kottaridi, Christine
Resta, Panagiota
Leventakou, Danai
Gioti, Katerina
Zygouras, Ioannis
Gouloumi, Alina-Roxani
Sakagiannis, Georgios
Alzahrani, Khalid J.
Venetikou, Maria S.
Anthouli-Anagnostopoulou, Fragkiski
Beloukas, Apostolos
author_facet Kottaridi, Christine
Resta, Panagiota
Leventakou, Danai
Gioti, Katerina
Zygouras, Ioannis
Gouloumi, Alina-Roxani
Sakagiannis, Georgios
Alzahrani, Khalid J.
Venetikou, Maria S.
Anthouli-Anagnostopoulou, Fragkiski
Beloukas, Apostolos
author_sort Kottaridi, Christine
collection PubMed
description Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer but there are very limited published data concerning the genetic variations of this HPV type in oropharyngeal cancer. In the present study, the genetic variations of HPV16 E6 gene sequences originated from a small cohort of Greek patients diagnosed with oropharyngeal cancer were assessed. The vast majority of the sequences clustered within the European variant branch. The T350G variation was found to be the predominant one. This finding may indicate the need for further studies that could explain the possible impact of this variant in the pathomechanisms of oropharyngeal cancer.
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spelling pubmed-94157112022-08-27 The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients Kottaridi, Christine Resta, Panagiota Leventakou, Danai Gioti, Katerina Zygouras, Ioannis Gouloumi, Alina-Roxani Sakagiannis, Georgios Alzahrani, Khalid J. Venetikou, Maria S. Anthouli-Anagnostopoulou, Fragkiski Beloukas, Apostolos Viruses Brief Report Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer but there are very limited published data concerning the genetic variations of this HPV type in oropharyngeal cancer. In the present study, the genetic variations of HPV16 E6 gene sequences originated from a small cohort of Greek patients diagnosed with oropharyngeal cancer were assessed. The vast majority of the sequences clustered within the European variant branch. The T350G variation was found to be the predominant one. This finding may indicate the need for further studies that could explain the possible impact of this variant in the pathomechanisms of oropharyngeal cancer. MDPI 2022-08-04 /pmc/articles/PMC9415711/ /pubmed/36016346 http://dx.doi.org/10.3390/v14081724 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Kottaridi, Christine
Resta, Panagiota
Leventakou, Danai
Gioti, Katerina
Zygouras, Ioannis
Gouloumi, Alina-Roxani
Sakagiannis, Georgios
Alzahrani, Khalid J.
Venetikou, Maria S.
Anthouli-Anagnostopoulou, Fragkiski
Beloukas, Apostolos
The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients
title The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients
title_full The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients
title_fullStr The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients
title_full_unstemmed The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients
title_short The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients
title_sort t350g variation of human papillomavirus 16 e6 gene prevails in oropharyngeal cancer from a small cohort of greek patients
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415711/
https://www.ncbi.nlm.nih.gov/pubmed/36016346
http://dx.doi.org/10.3390/v14081724
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