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The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D(3) and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities
In this paper, we report an efficient synthetic route for the 23,23-difluoro-25-hydroxyvitamin D(3) (5) and its 24-hydroxylated analogues (7,8), which are candidates for the CYP24A1 main metabolites of 5. The key fragments, 23,23-difluoro-CD-ring precursors (9–11), were synthesized starting from Inh...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415778/ https://www.ncbi.nlm.nih.gov/pubmed/36014588 http://dx.doi.org/10.3390/molecules27165352 |