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Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies

More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to ob...

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Autores principales: Poteser, Michael, Laguzzi, Federica, Schettgen, Thomas, Vogel, Nina, Weber, Till, Zimmermann, Philipp, Hahn, Domenica, Kolossa-Gehring, Marike, Namorado, Sónia, Van Nieuwenhuyse, An, Appenzeller, Brice, Halldórsson, Thórhallur I., Eiríksdóttir, Ása, Haug, Line Småstuen, Thomsen, Cathrine, Barbone, Fabio, Rosolen, Valentina, Rambaud, Loïc, Riou, Margaux, Göen, Thomas, Nübler, Stefanie, Schäfer, Moritz, Haji Abbas Zarrabi, Karin, Gilles, Liese, Martin, Laura Rodriguez, Schoeters, Greet, Sepai, Ovnair, Govarts, Eva, Moshammer, Hanns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415789/
https://www.ncbi.nlm.nih.gov/pubmed/36006160
http://dx.doi.org/10.3390/toxics10080481
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author Poteser, Michael
Laguzzi, Federica
Schettgen, Thomas
Vogel, Nina
Weber, Till
Zimmermann, Philipp
Hahn, Domenica
Kolossa-Gehring, Marike
Namorado, Sónia
Van Nieuwenhuyse, An
Appenzeller, Brice
Halldórsson, Thórhallur I.
Eiríksdóttir, Ása
Haug, Line Småstuen
Thomsen, Cathrine
Barbone, Fabio
Rosolen, Valentina
Rambaud, Loïc
Riou, Margaux
Göen, Thomas
Nübler, Stefanie
Schäfer, Moritz
Haji Abbas Zarrabi, Karin
Gilles, Liese
Martin, Laura Rodriguez
Schoeters, Greet
Sepai, Ovnair
Govarts, Eva
Moshammer, Hanns
author_facet Poteser, Michael
Laguzzi, Federica
Schettgen, Thomas
Vogel, Nina
Weber, Till
Zimmermann, Philipp
Hahn, Domenica
Kolossa-Gehring, Marike
Namorado, Sónia
Van Nieuwenhuyse, An
Appenzeller, Brice
Halldórsson, Thórhallur I.
Eiríksdóttir, Ása
Haug, Line Småstuen
Thomsen, Cathrine
Barbone, Fabio
Rosolen, Valentina
Rambaud, Loïc
Riou, Margaux
Göen, Thomas
Nübler, Stefanie
Schäfer, Moritz
Haji Abbas Zarrabi, Karin
Gilles, Liese
Martin, Laura Rodriguez
Schoeters, Greet
Sepai, Ovnair
Govarts, Eva
Moshammer, Hanns
author_sort Poteser, Michael
collection PubMed
description More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.
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spelling pubmed-94157892022-08-27 Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies Poteser, Michael Laguzzi, Federica Schettgen, Thomas Vogel, Nina Weber, Till Zimmermann, Philipp Hahn, Domenica Kolossa-Gehring, Marike Namorado, Sónia Van Nieuwenhuyse, An Appenzeller, Brice Halldórsson, Thórhallur I. Eiríksdóttir, Ása Haug, Line Småstuen Thomsen, Cathrine Barbone, Fabio Rosolen, Valentina Rambaud, Loïc Riou, Margaux Göen, Thomas Nübler, Stefanie Schäfer, Moritz Haji Abbas Zarrabi, Karin Gilles, Liese Martin, Laura Rodriguez Schoeters, Greet Sepai, Ovnair Govarts, Eva Moshammer, Hanns Toxics Article More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children. MDPI 2022-08-17 /pmc/articles/PMC9415789/ /pubmed/36006160 http://dx.doi.org/10.3390/toxics10080481 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Poteser, Michael
Laguzzi, Federica
Schettgen, Thomas
Vogel, Nina
Weber, Till
Zimmermann, Philipp
Hahn, Domenica
Kolossa-Gehring, Marike
Namorado, Sónia
Van Nieuwenhuyse, An
Appenzeller, Brice
Halldórsson, Thórhallur I.
Eiríksdóttir, Ása
Haug, Line Småstuen
Thomsen, Cathrine
Barbone, Fabio
Rosolen, Valentina
Rambaud, Loïc
Riou, Margaux
Göen, Thomas
Nübler, Stefanie
Schäfer, Moritz
Haji Abbas Zarrabi, Karin
Gilles, Liese
Martin, Laura Rodriguez
Schoeters, Greet
Sepai, Ovnair
Govarts, Eva
Moshammer, Hanns
Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies
title Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies
title_full Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies
title_fullStr Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies
title_full_unstemmed Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies
title_short Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies
title_sort time trends of acrylamide exposure in europe: combined analysis of published reports and current hbm4eu studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415789/
https://www.ncbi.nlm.nih.gov/pubmed/36006160
http://dx.doi.org/10.3390/toxics10080481
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