Phosphodiesterase 10A Inhibition Modulates the Corticostriatal Activity and L-DOPA-Induced Dyskinesia

The facilitation of corticostriatal transmission is modulated by the pharmacological inhibition of striatal phosphodiesterase 10A (PDE10A). Since L-DOPA-induced dyskinesia is associated with abnormal corticostriatal transmission, we hypothesized that inhibition of PDE10A would modulate L-DOPA-induce...

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Detalles Bibliográficos
Autores principales: Guimarães, Rayanne Poletti, Ribeiro, Danilo Leandro, Dos Santos, Keila Bariotto, Talarico, Carlos Henrique Zanello, Godoy, Lívea Dornela, Padovan-Neto, Fernando E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415800/
https://www.ncbi.nlm.nih.gov/pubmed/36015095
http://dx.doi.org/10.3390/ph15080947

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