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To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria

Regulated cell death (RCD) is central to the development, integrity, and functionality of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal phenomenon in all life domains. Cyanobacteria are of specific interest due to their importance in aquatic and terres...

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Autores principales: Barteneva, Natasha S., Meirkhanova, Ayagoz, Malashenkov, Dmitry, Vorobjev, Ivan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415839/
https://www.ncbi.nlm.nih.gov/pubmed/36014075
http://dx.doi.org/10.3390/microorganisms10081657
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author Barteneva, Natasha S.
Meirkhanova, Ayagoz
Malashenkov, Dmitry
Vorobjev, Ivan A.
author_facet Barteneva, Natasha S.
Meirkhanova, Ayagoz
Malashenkov, Dmitry
Vorobjev, Ivan A.
author_sort Barteneva, Natasha S.
collection PubMed
description Regulated cell death (RCD) is central to the development, integrity, and functionality of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal phenomenon in all life domains. Cyanobacteria are of specific interest due to their importance in aquatic and terrestrial habitats and their role as primary producers in global nutrient cycling. Current knowledge on cyanobacterial RCD is based mainly on biochemical and morphological observations, often by methods directly transferred from vertebrate research and with limited understanding of the molecular genetic basis. However, the metabolism of different cyanobacteria groups relies on photosynthesis and nitrogen fixation, whereas mitochondria are the central executioner of cell death in vertebrates. Moreover, cyanobacteria chosen as biological models in RCD studies are mainly colonial or filamentous multicellular organisms. On the other hand, unicellular cyanobacteria have regulated programs of cellular survival (RCS) such as chlorosis and post-chlorosis resuscitation. The co-existence of different genetically regulated programs in cyanobacterial populations may have been a top engine in life diversification. Development of cyanobacteria-specific methods for identification and characterization of RCD and wider use of single-cell analysis combined with intelligent image-based cell sorting and metagenomics would shed more light on the underlying molecular mechanisms and help us to address the complex colonial interactions during these events. In this review, we focus on the functional implications of RCD in cyanobacterial communities.
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spelling pubmed-94158392022-08-27 To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria Barteneva, Natasha S. Meirkhanova, Ayagoz Malashenkov, Dmitry Vorobjev, Ivan A. Microorganisms Review Regulated cell death (RCD) is central to the development, integrity, and functionality of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal phenomenon in all life domains. Cyanobacteria are of specific interest due to their importance in aquatic and terrestrial habitats and their role as primary producers in global nutrient cycling. Current knowledge on cyanobacterial RCD is based mainly on biochemical and morphological observations, often by methods directly transferred from vertebrate research and with limited understanding of the molecular genetic basis. However, the metabolism of different cyanobacteria groups relies on photosynthesis and nitrogen fixation, whereas mitochondria are the central executioner of cell death in vertebrates. Moreover, cyanobacteria chosen as biological models in RCD studies are mainly colonial or filamentous multicellular organisms. On the other hand, unicellular cyanobacteria have regulated programs of cellular survival (RCS) such as chlorosis and post-chlorosis resuscitation. The co-existence of different genetically regulated programs in cyanobacterial populations may have been a top engine in life diversification. Development of cyanobacteria-specific methods for identification and characterization of RCD and wider use of single-cell analysis combined with intelligent image-based cell sorting and metagenomics would shed more light on the underlying molecular mechanisms and help us to address the complex colonial interactions during these events. In this review, we focus on the functional implications of RCD in cyanobacterial communities. MDPI 2022-08-17 /pmc/articles/PMC9415839/ /pubmed/36014075 http://dx.doi.org/10.3390/microorganisms10081657 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Barteneva, Natasha S.
Meirkhanova, Ayagoz
Malashenkov, Dmitry
Vorobjev, Ivan A.
To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria
title To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria
title_full To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria
title_fullStr To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria
title_full_unstemmed To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria
title_short To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria
title_sort to die or not to die—regulated cell death and survival in cyanobacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415839/
https://www.ncbi.nlm.nih.gov/pubmed/36014075
http://dx.doi.org/10.3390/microorganisms10081657
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