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Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart

Overexpression of the human epidermal growth factor receptor 2 (HER2) in breast and gastric cancer is exploited for targeted therapy using monoclonal antibodies and antibody-drug conjugates. Small engineered scaffold proteins, such as the albumin binding domain (ABD) derived affinity proteins (ADAPT...

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Detalles Bibliográficos
Autores principales:	Garousi, Javad, Xu, Tianqi, Liu, Yongsheng, Vorontsova, Olga, Hober, Sophia, Orlova, Anna, Tolmachev, Vladimir, Gräslund, Torbjörn, Vorobyeva, Anzhelika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415843/ https://www.ncbi.nlm.nih.gov/pubmed/36015242 http://dx.doi.org/10.3390/pharmaceutics14081612

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