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Structural and Functional Analysis of CEX Fractions Collected from a Novel Avastin(®) Biosimilar Candidate and Its Innovator: A Comparative Study

Avastin(®) is a humanized recombinant monoclonal antibody used to treat cancer by targeting VEGF-A to inhibit angiogenesis. SIMAB054, an Avastin(®) biosimilar candidate developed in this study, showed a different charge variant profile than its innovator. Thus, it is fractionated into acidic, main,...

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Detalles Bibliográficos
Autores principales:	Gurel, Busra, Berksoz, Melike, Capkin, Eda, Parlar, Ayhan, Pala, Meltem Corbacioglu, Ozkan, Aylin, Capan, Yılmaz, Daglikoca, Duygu Emine, Yuce, Meral
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415858/ https://www.ncbi.nlm.nih.gov/pubmed/36015197 http://dx.doi.org/10.3390/pharmaceutics14081571

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