Cargando…
Design and Prototype Fabrication of a Cost-Effective Microneedle Drug Delivery Apparatus Using Fused Filament Fabrication, Liquid Crystal Display and Semi-Solid Extrusion 3D Printing Technologies
The current study describes the design of a cost-effective drug delivery apparatus that can be manufactured, assembled, and utilized as easily and quickly as possible, minimizing the time and expense of the supply chain. This apparatus could become a realistic alternative method of providing a vacci...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415897/ https://www.ncbi.nlm.nih.gov/pubmed/36014241 http://dx.doi.org/10.3390/mi13081319 |
_version_ | 1784776345936461824 |
---|---|
author | Papadimitriou, Petros Andriotis, Eleftherios G. Fatouros, Dimitrios Tzetzis, Dimitrios |
author_facet | Papadimitriou, Petros Andriotis, Eleftherios G. Fatouros, Dimitrios Tzetzis, Dimitrios |
author_sort | Papadimitriou, Petros |
collection | PubMed |
description | The current study describes the design of a cost-effective drug delivery apparatus that can be manufactured, assembled, and utilized as easily and quickly as possible, minimizing the time and expense of the supply chain. This apparatus could become a realistic alternative method of providing a vaccine or drug in harsh circumstances, including humanitarian disasters or a lack of medical and nursing staff, conditions that are frequently observed in developing countries. Simultaneously, with the use of microneedles (MNs), the apparatus can benefit from the numerous advantages offered by them during administration. The hollow microneedles in particular are internally perforated and are capable of delivering the active substance to the skin. The apparatus was designed with appropriate details in computer aided design software, and various 3D printing technologies were utilized in order to fabricate the prototype. The parts that required minimum accuracy, such as the main body of the apparatus, were fabricated with fused filament fabrication. The internal parts and the hollow microneedles were fabricated with liquid crystal display, and the substance for the drug loading carrier, which was an alginate gel cylinder, was fabricated with semi-solid extrusion 3D printing. |
format | Online Article Text |
id | pubmed-9415897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94158972022-08-27 Design and Prototype Fabrication of a Cost-Effective Microneedle Drug Delivery Apparatus Using Fused Filament Fabrication, Liquid Crystal Display and Semi-Solid Extrusion 3D Printing Technologies Papadimitriou, Petros Andriotis, Eleftherios G. Fatouros, Dimitrios Tzetzis, Dimitrios Micromachines (Basel) Article The current study describes the design of a cost-effective drug delivery apparatus that can be manufactured, assembled, and utilized as easily and quickly as possible, minimizing the time and expense of the supply chain. This apparatus could become a realistic alternative method of providing a vaccine or drug in harsh circumstances, including humanitarian disasters or a lack of medical and nursing staff, conditions that are frequently observed in developing countries. Simultaneously, with the use of microneedles (MNs), the apparatus can benefit from the numerous advantages offered by them during administration. The hollow microneedles in particular are internally perforated and are capable of delivering the active substance to the skin. The apparatus was designed with appropriate details in computer aided design software, and various 3D printing technologies were utilized in order to fabricate the prototype. The parts that required minimum accuracy, such as the main body of the apparatus, were fabricated with fused filament fabrication. The internal parts and the hollow microneedles were fabricated with liquid crystal display, and the substance for the drug loading carrier, which was an alginate gel cylinder, was fabricated with semi-solid extrusion 3D printing. MDPI 2022-08-15 /pmc/articles/PMC9415897/ /pubmed/36014241 http://dx.doi.org/10.3390/mi13081319 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Papadimitriou, Petros Andriotis, Eleftherios G. Fatouros, Dimitrios Tzetzis, Dimitrios Design and Prototype Fabrication of a Cost-Effective Microneedle Drug Delivery Apparatus Using Fused Filament Fabrication, Liquid Crystal Display and Semi-Solid Extrusion 3D Printing Technologies |
title | Design and Prototype Fabrication of a Cost-Effective Microneedle Drug Delivery Apparatus Using Fused Filament Fabrication, Liquid Crystal Display and Semi-Solid Extrusion 3D Printing Technologies |
title_full | Design and Prototype Fabrication of a Cost-Effective Microneedle Drug Delivery Apparatus Using Fused Filament Fabrication, Liquid Crystal Display and Semi-Solid Extrusion 3D Printing Technologies |
title_fullStr | Design and Prototype Fabrication of a Cost-Effective Microneedle Drug Delivery Apparatus Using Fused Filament Fabrication, Liquid Crystal Display and Semi-Solid Extrusion 3D Printing Technologies |
title_full_unstemmed | Design and Prototype Fabrication of a Cost-Effective Microneedle Drug Delivery Apparatus Using Fused Filament Fabrication, Liquid Crystal Display and Semi-Solid Extrusion 3D Printing Technologies |
title_short | Design and Prototype Fabrication of a Cost-Effective Microneedle Drug Delivery Apparatus Using Fused Filament Fabrication, Liquid Crystal Display and Semi-Solid Extrusion 3D Printing Technologies |
title_sort | design and prototype fabrication of a cost-effective microneedle drug delivery apparatus using fused filament fabrication, liquid crystal display and semi-solid extrusion 3d printing technologies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415897/ https://www.ncbi.nlm.nih.gov/pubmed/36014241 http://dx.doi.org/10.3390/mi13081319 |
work_keys_str_mv | AT papadimitrioupetros designandprototypefabricationofacosteffectivemicroneedledrugdeliveryapparatususingfusedfilamentfabricationliquidcrystaldisplayandsemisolidextrusion3dprintingtechnologies AT andriotiseleftheriosg designandprototypefabricationofacosteffectivemicroneedledrugdeliveryapparatususingfusedfilamentfabricationliquidcrystaldisplayandsemisolidextrusion3dprintingtechnologies AT fatourosdimitrios designandprototypefabricationofacosteffectivemicroneedledrugdeliveryapparatususingfusedfilamentfabricationliquidcrystaldisplayandsemisolidextrusion3dprintingtechnologies AT tzetzisdimitrios designandprototypefabricationofacosteffectivemicroneedledrugdeliveryapparatususingfusedfilamentfabricationliquidcrystaldisplayandsemisolidextrusion3dprintingtechnologies |