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Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response
Pediatric cancer treatment has evolved significantly in recent decades. The implementation of risk stratification strategies and the selection of evidence-based chemotherapy combinations have improved survival outcomes. However, there is large interindividual variability in terms of chemotherapy-rel...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415926/ https://www.ncbi.nlm.nih.gov/pubmed/36015138 http://dx.doi.org/10.3390/ph15080990 |
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author | Kamath, Ashwin Srinivasamurthy, Suresh Kumar Chowta, Mukta N. Ullal, Sheetal D. Daali, Youssef Chakradhara Rao, Uppugunduri S. |
author_facet | Kamath, Ashwin Srinivasamurthy, Suresh Kumar Chowta, Mukta N. Ullal, Sheetal D. Daali, Youssef Chakradhara Rao, Uppugunduri S. |
author_sort | Kamath, Ashwin |
collection | PubMed |
description | Pediatric cancer treatment has evolved significantly in recent decades. The implementation of risk stratification strategies and the selection of evidence-based chemotherapy combinations have improved survival outcomes. However, there is large interindividual variability in terms of chemotherapy-related toxicities and, sometimes, the response among this population. This variability is partly attributed to the functional variability of drug-metabolizing enzymes (DME) and drug transporters (DTS) involved in the process of absorption, distribution, metabolism and excretion (ADME). The DTS, being ubiquitous, affects drug disposition across membranes and has relevance in determining chemotherapy response in pediatric cancer patients. Among the factors affecting DTS function, ontogeny or maturation is important in the pediatric population. In this narrative review, we describe the role of drug uptake/efflux transporters in defining pediatric chemotherapy-treatment-related toxicities and responses. Developmental differences in DTS and the consequent implications are also briefly discussed for the most commonly used chemotherapeutic drugs in the pediatric population. |
format | Online Article Text |
id | pubmed-9415926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94159262022-08-27 Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response Kamath, Ashwin Srinivasamurthy, Suresh Kumar Chowta, Mukta N. Ullal, Sheetal D. Daali, Youssef Chakradhara Rao, Uppugunduri S. Pharmaceuticals (Basel) Review Pediatric cancer treatment has evolved significantly in recent decades. The implementation of risk stratification strategies and the selection of evidence-based chemotherapy combinations have improved survival outcomes. However, there is large interindividual variability in terms of chemotherapy-related toxicities and, sometimes, the response among this population. This variability is partly attributed to the functional variability of drug-metabolizing enzymes (DME) and drug transporters (DTS) involved in the process of absorption, distribution, metabolism and excretion (ADME). The DTS, being ubiquitous, affects drug disposition across membranes and has relevance in determining chemotherapy response in pediatric cancer patients. Among the factors affecting DTS function, ontogeny or maturation is important in the pediatric population. In this narrative review, we describe the role of drug uptake/efflux transporters in defining pediatric chemotherapy-treatment-related toxicities and responses. Developmental differences in DTS and the consequent implications are also briefly discussed for the most commonly used chemotherapeutic drugs in the pediatric population. MDPI 2022-08-11 /pmc/articles/PMC9415926/ /pubmed/36015138 http://dx.doi.org/10.3390/ph15080990 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kamath, Ashwin Srinivasamurthy, Suresh Kumar Chowta, Mukta N. Ullal, Sheetal D. Daali, Youssef Chakradhara Rao, Uppugunduri S. Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response |
title | Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response |
title_full | Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response |
title_fullStr | Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response |
title_full_unstemmed | Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response |
title_short | Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response |
title_sort | role of drug transporters in elucidating inter-individual variability in pediatric chemotherapy-related toxicities and response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415926/ https://www.ncbi.nlm.nih.gov/pubmed/36015138 http://dx.doi.org/10.3390/ph15080990 |
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