Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius

Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversit...

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Detalles Bibliográficos
Autores principales: Wegener, Alice, Duim, Birgitta, van der Graaf-van Bloois, Linda, Zomer, Aldert L., Visser, Caroline E., Spaninks, Mirlin, Timmerman, Arjen J., Wagenaar, Jaap A., Broens, Els M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415945/
https://www.ncbi.nlm.nih.gov/pubmed/36014971
http://dx.doi.org/10.3390/pathogens11080850
Descripción
Sumario:Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversity and distribution of plasmids and antimicrobial resistance genes identified related and unrelated isolates in both households. Our study shows that within-host bacterial diversity is present in S. pseudintermedius, demonstrating that multiple isolates from each host should preferably be sequenced to study transmission dynamics.

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