Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius

Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversit...

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Autores principales: Wegener, Alice, Duim, Birgitta, van der Graaf-van Bloois, Linda, Zomer, Aldert L., Visser, Caroline E., Spaninks, Mirlin, Timmerman, Arjen J., Wagenaar, Jaap A., Broens, Els M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415945/
https://www.ncbi.nlm.nih.gov/pubmed/36014971
http://dx.doi.org/10.3390/pathogens11080850
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author Wegener, Alice
Duim, Birgitta
van der Graaf-van Bloois, Linda
Zomer, Aldert L.
Visser, Caroline E.
Spaninks, Mirlin
Timmerman, Arjen J.
Wagenaar, Jaap A.
Broens, Els M.
author_facet Wegener, Alice
Duim, Birgitta
van der Graaf-van Bloois, Linda
Zomer, Aldert L.
Visser, Caroline E.
Spaninks, Mirlin
Timmerman, Arjen J.
Wagenaar, Jaap A.
Broens, Els M.
author_sort Wegener, Alice
collection PubMed
description Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversity and distribution of plasmids and antimicrobial resistance genes identified related and unrelated isolates in both households. Our study shows that within-host bacterial diversity is present in S. pseudintermedius, demonstrating that multiple isolates from each host should preferably be sequenced to study transmission dynamics.
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spelling pubmed-94159452022-08-27 Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius Wegener, Alice Duim, Birgitta van der Graaf-van Bloois, Linda Zomer, Aldert L. Visser, Caroline E. Spaninks, Mirlin Timmerman, Arjen J. Wagenaar, Jaap A. Broens, Els M. Pathogens Case Report Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversity and distribution of plasmids and antimicrobial resistance genes identified related and unrelated isolates in both households. Our study shows that within-host bacterial diversity is present in S. pseudintermedius, demonstrating that multiple isolates from each host should preferably be sequenced to study transmission dynamics. MDPI 2022-07-28 /pmc/articles/PMC9415945/ /pubmed/36014971 http://dx.doi.org/10.3390/pathogens11080850 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Wegener, Alice
Duim, Birgitta
van der Graaf-van Bloois, Linda
Zomer, Aldert L.
Visser, Caroline E.
Spaninks, Mirlin
Timmerman, Arjen J.
Wagenaar, Jaap A.
Broens, Els M.
Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius
title Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius
title_full Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius
title_fullStr Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius
title_full_unstemmed Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius
title_short Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius
title_sort within-household transmission and bacterial diversity of staphylococcus pseudintermedius
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415945/
https://www.ncbi.nlm.nih.gov/pubmed/36014971
http://dx.doi.org/10.3390/pathogens11080850
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