Cargando…

Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study

Partial replacement of saturated fatty acids (SFA) with unsaturated fatty acids is recommended to reduce cardiovascular disease (CVD) risk. Monounsaturated fatty acids (MUFA), including oleic acid, are associated with lower CVD risk. Measurement of flow-mediated dilation of the brachial artery (FMD)...

Descripción completa

Detalles Bibliográficos
Autores principales: Davis, Kristin M., Petersen, Kristina S., Bowen, Kate J., Jones, Peter J. H., Taylor, Carla G., Zahradka, Peter, Letourneau, Karen, Perera, Danielle, Wilson, Angela, Wagner, Paul R., Kris-Etherton, Penny M., West, Sheila G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416081/
https://www.ncbi.nlm.nih.gov/pubmed/36014910
http://dx.doi.org/10.3390/nu14163404
_version_ 1784776391633403904
author Davis, Kristin M.
Petersen, Kristina S.
Bowen, Kate J.
Jones, Peter J. H.
Taylor, Carla G.
Zahradka, Peter
Letourneau, Karen
Perera, Danielle
Wilson, Angela
Wagner, Paul R.
Kris-Etherton, Penny M.
West, Sheila G.
author_facet Davis, Kristin M.
Petersen, Kristina S.
Bowen, Kate J.
Jones, Peter J. H.
Taylor, Carla G.
Zahradka, Peter
Letourneau, Karen
Perera, Danielle
Wilson, Angela
Wagner, Paul R.
Kris-Etherton, Penny M.
West, Sheila G.
author_sort Davis, Kristin M.
collection PubMed
description Partial replacement of saturated fatty acids (SFA) with unsaturated fatty acids is recommended to reduce cardiovascular disease (CVD) risk. Monounsaturated fatty acids (MUFA), including oleic acid, are associated with lower CVD risk. Measurement of flow-mediated dilation of the brachial artery (FMD) is the gold standard for measuring endothelial function and predicts CVD risk. This study examined the effect of partially replacing SFA with MUFA from conventional canola oil and high-oleic acid canola oil on FMD. Participants (n = 31) with an elevated waist circumference plus ≥1 additional metabolic syndrome criterion completed FMD measures as part of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a multi-center, double-blind, three-period crossover, controlled feeding randomized trial. Diet periods were 6 weeks, separated by ≥4-week washouts. Experimental diets were provided during all feeding periods. Diets only differed by the fatty acid profile of the oils: canola oil (CO; 17.5% energy from MUFA, 9.2% polyunsaturated fatty acids (PUFA), 6.6% SFA), high-oleic acid canola oil (HOCO; 19.1% MUFA, 7.0% PUFA, 6.4% SFA), and a control oil blend (CON; 11% MUFA, 10% PUFA, 12% SFA). Multilevel models were used to examine the effect of the diets on FMD. No significant between-diet differences were observed for average brachial artery diameter (CO: 6.70 ± 0.15 mm, HOCO: 6.57 ± 0.15 mm, CON: 6.73 ± 0.14 mm; p = 0.72), peak brachial artery diameter (CO: 7.11 ± 0.15 mm, HOCO: 7.02 ± 0.15 mm, CON: 6.41 ± 0.48 mm; p = 0.80), or FMD (CO: 6.32 ± 0.51%, HOCO: 6.96 ± 0.49%, CON: 6.41 ± 0.48%; p = 0.81). Partial replacement of SFA with MUFA from CO and HOCO had no effect on FMD in participants with or at risk of metabolic syndrome.
format Online
Article
Text
id pubmed-9416081
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94160812022-08-27 Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study Davis, Kristin M. Petersen, Kristina S. Bowen, Kate J. Jones, Peter J. H. Taylor, Carla G. Zahradka, Peter Letourneau, Karen Perera, Danielle Wilson, Angela Wagner, Paul R. Kris-Etherton, Penny M. West, Sheila G. Nutrients Article Partial replacement of saturated fatty acids (SFA) with unsaturated fatty acids is recommended to reduce cardiovascular disease (CVD) risk. Monounsaturated fatty acids (MUFA), including oleic acid, are associated with lower CVD risk. Measurement of flow-mediated dilation of the brachial artery (FMD) is the gold standard for measuring endothelial function and predicts CVD risk. This study examined the effect of partially replacing SFA with MUFA from conventional canola oil and high-oleic acid canola oil on FMD. Participants (n = 31) with an elevated waist circumference plus ≥1 additional metabolic syndrome criterion completed FMD measures as part of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a multi-center, double-blind, three-period crossover, controlled feeding randomized trial. Diet periods were 6 weeks, separated by ≥4-week washouts. Experimental diets were provided during all feeding periods. Diets only differed by the fatty acid profile of the oils: canola oil (CO; 17.5% energy from MUFA, 9.2% polyunsaturated fatty acids (PUFA), 6.6% SFA), high-oleic acid canola oil (HOCO; 19.1% MUFA, 7.0% PUFA, 6.4% SFA), and a control oil blend (CON; 11% MUFA, 10% PUFA, 12% SFA). Multilevel models were used to examine the effect of the diets on FMD. No significant between-diet differences were observed for average brachial artery diameter (CO: 6.70 ± 0.15 mm, HOCO: 6.57 ± 0.15 mm, CON: 6.73 ± 0.14 mm; p = 0.72), peak brachial artery diameter (CO: 7.11 ± 0.15 mm, HOCO: 7.02 ± 0.15 mm, CON: 6.41 ± 0.48 mm; p = 0.80), or FMD (CO: 6.32 ± 0.51%, HOCO: 6.96 ± 0.49%, CON: 6.41 ± 0.48%; p = 0.81). Partial replacement of SFA with MUFA from CO and HOCO had no effect on FMD in participants with or at risk of metabolic syndrome. MDPI 2022-08-18 /pmc/articles/PMC9416081/ /pubmed/36014910 http://dx.doi.org/10.3390/nu14163404 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Davis, Kristin M.
Petersen, Kristina S.
Bowen, Kate J.
Jones, Peter J. H.
Taylor, Carla G.
Zahradka, Peter
Letourneau, Karen
Perera, Danielle
Wilson, Angela
Wagner, Paul R.
Kris-Etherton, Penny M.
West, Sheila G.
Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study
title Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study
title_full Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study
title_fullStr Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study
title_full_unstemmed Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study
title_short Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study
title_sort effects of diets enriched with conventional or high-oleic canola oils on vascular endothelial function: a sub-study of the canola oil multi-centre intervention trial 2 (comit-2), a randomized crossover controlled feeding study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416081/
https://www.ncbi.nlm.nih.gov/pubmed/36014910
http://dx.doi.org/10.3390/nu14163404
work_keys_str_mv AT daviskristinm effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT petersenkristinas effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT bowenkatej effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT jonespeterjh effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT taylorcarlag effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT zahradkapeter effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT letourneaukaren effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT pereradanielle effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT wilsonangela effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT wagnerpaulr effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT krisethertonpennym effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy
AT westsheilag effectsofdietsenrichedwithconventionalorhigholeiccanolaoilsonvascularendothelialfunctionasubstudyofthecanolaoilmulticentreinterventiontrial2comit2arandomizedcrossovercontrolledfeedingstudy