Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides

New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds...

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Detalles Bibliográficos
Autores principales: Sudarikov, Denis V., Gyrdymova, Yulia V., Borisov, Alexander V., Lukiyanova, Julia M., Rumyantcev, Roman V., Shevchenko, Oksana G., Baidamshina, Diana R., Zakarova, Nargiza D., Kayumov, Airat R., Sinegubova, Ekaterina O., Volobueva, Alexandrina S., Zarubaev, Vladimir V., Rubtsova, Svetlana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416111/
https://www.ncbi.nlm.nih.gov/pubmed/36014334
http://dx.doi.org/10.3390/molecules27165101
Descripción
Sumario:New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.

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