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Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides
New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416111/ https://www.ncbi.nlm.nih.gov/pubmed/36014334 http://dx.doi.org/10.3390/molecules27165101 |
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| author | Sudarikov, Denis V. Gyrdymova, Yulia V. Borisov, Alexander V. Lukiyanova, Julia M. Rumyantcev, Roman V. Shevchenko, Oksana G. Baidamshina, Diana R. Zakarova, Nargiza D. Kayumov, Airat R. Sinegubova, Ekaterina O. Volobueva, Alexandrina S. Zarubaev, Vladimir V. Rubtsova, Svetlana A. |
| author_facet | Sudarikov, Denis V. Gyrdymova, Yulia V. Borisov, Alexander V. Lukiyanova, Julia M. Rumyantcev, Roman V. Shevchenko, Oksana G. Baidamshina, Diana R. Zakarova, Nargiza D. Kayumov, Airat R. Sinegubova, Ekaterina O. Volobueva, Alexandrina S. Zarubaev, Vladimir V. Rubtsova, Svetlana A. |
| author_sort | Sudarikov, Denis V. |
| collection | PubMed |
| description | New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity. |
| format | Online Article Text |
| id | pubmed-9416111 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94161112022-08-27 Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides Sudarikov, Denis V. Gyrdymova, Yulia V. Borisov, Alexander V. Lukiyanova, Julia M. Rumyantcev, Roman V. Shevchenko, Oksana G. Baidamshina, Diana R. Zakarova, Nargiza D. Kayumov, Airat R. Sinegubova, Ekaterina O. Volobueva, Alexandrina S. Zarubaev, Vladimir V. Rubtsova, Svetlana A. Molecules Article New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity. MDPI 2022-08-10 /pmc/articles/PMC9416111/ /pubmed/36014334 http://dx.doi.org/10.3390/molecules27165101 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Sudarikov, Denis V. Gyrdymova, Yulia V. Borisov, Alexander V. Lukiyanova, Julia M. Rumyantcev, Roman V. Shevchenko, Oksana G. Baidamshina, Diana R. Zakarova, Nargiza D. Kayumov, Airat R. Sinegubova, Ekaterina O. Volobueva, Alexandrina S. Zarubaev, Vladimir V. Rubtsova, Svetlana A. Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides |
| title | Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides |
| title_full | Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides |
| title_fullStr | Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides |
| title_full_unstemmed | Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides |
| title_short | Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides |
| title_sort | synthesis and biological activity of unsymmetrical monoterpenylhetaryl disulfides |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416111/ https://www.ncbi.nlm.nih.gov/pubmed/36014334 http://dx.doi.org/10.3390/molecules27165101 |
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