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Development and Validation of [(3)H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs

GluN2B-enriched N-methyl-D-aspartate receptors (NMDARs) are implicated in several neurodegenerative and psychiatric diseases, such as Alzheimer’s disease. No clinically valid GluN1/2B therapeutic exists due to a lack of selective GluN2B imaging tools, and the state-of-the-art [(3)H]ifenprodil shows...

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Detalles Bibliográficos
Autores principales:	Ahmed, Hazem, Gisler, Livio, Elghazawy, Nehal H., Keller, Claudia, Sippl, Wolfgang, Liang, Steven H., Haider, Ahmed, Ametamey, Simon M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416150/ https://www.ncbi.nlm.nih.gov/pubmed/36015108 http://dx.doi.org/10.3390/ph15080960

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